SNW1 and ACTN2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		SNW1	ACTN2
Gene Name		SNW domain containing 1	actinin, alpha 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Positive Transcription Elongation Factor Complex B Nuclear Matrix Catalytic Step 2 Spliceosome SMAD3-SMAD4 Protein Complex	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Poly(A) RNA Binding SMAD Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Positive Regulation Of Histone H3-K4 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		58 interactors: ACTN2 ASCC2 CEP55 CIR1 CXorf56 DAXX EP300 GOLGA2 HDAC2 IKBKG IKZF1 JDP2 KRT40 LRP2BP LZTS2 MAGEA1 MAPK6 MEN1 MFAP1 MSL1 MTUS2 NCOR1 NCOR2 NHP2L1 NOTCH1 NOTCH3 NR0B1 NR0B2 PABPN1 PCBD2 PGR PPIL1 PRKAA2 RARA RB1 RBL1 RBL2 RBPJ RINT1 RXRA SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SRC TEX11 TFIP11 TNNT1 TOP1 TRAF1 TRIM15 TTC14 VAV2 VDR ZSCAN1	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		22938	88
HPRD ID		04340	00019
Ensembl ID		ENSG00000100603	ENSG00000077522
Uniprot IDs		G3V3A4 Q13573	B2RCS5 P35609 Q59FD9
PDB IDs			1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Chromatin Modification Organ Development Regulation Of Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Signaling Regulation Of Binding Response To Transforming Growth Factor Beta Positive Regulation Of Metabolic Process Cell Cycle Chromosome Organization Negative Regulation Of Cell Differentiation	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		buffer complicates consist demonstration deprotection ends exploit feasibility foci knock nucleoprotein pot1 pseudogene rap1 repetitive scaling shelterin shortening skiip telomere telomeres telomeric tif tin2 tpp1 trf1 trf2 ttaggg visualized	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		buffer complicates consist demonstration deprotection ends exploit feasibility foci knock nucleoprotein pot1 pseudogene rap1 repetitive scaling shelterin shortening skiip telomere telomeres telomeric tif tin2 tpp1 trf1 trf2 ttaggg visualized	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?