SNW1 and SKI

Number of citations of the paper that reports this interaction (PubMedID 11522815)
37

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SNW1	SKI
Description		SNW domain containing 1	SKI proto-oncogene
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Nuclear Body PML Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Nuclear Vitamin D Receptor Binding Nuclear Retinoic Acid Receptor Binding SMAD Binding Nuclear Androgen Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding SMAD Binding Histone Deacetylase Inhibitor Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Regulation Of Neurogenesis Roof Of Mouth Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Muscle Structure Development
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm	Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Coronary artery disease ( 29212778) Liver enzyme levels (alanine transaminase) ( 33972514) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 30046033 32439900) Systolic blood pressure ( 30224653) Urate levels ( 31578528)
Interacting Genes		122 interacting genes: ABLIM3 ACTN2 APOBEC3C AR ASCC2 BAG4 BCAS2 BICD2 BYSL C1orf216 CCDC125 CEBPA CEP55 CEP70 CIRSR CPSF7 CSDE1 CTBP1 CWF19L2 DAXX DMRTB1 EP300 ERCC3 EXOSC5 EXOSC7 EXOSC8 FAM90A1 FTSJ3 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT31 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NIN NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OGT OSTF1 PABPN1 PCBD2 PEG10 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBFOX2 RBL1 RBL2 RBM22 RBPJ RBPMS RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 THOC1 TNNT1 TOP1 TRAF1 TRAK1 TRIM15 TRIM23 TRIM55 TRIM63 TSNAXIP1 TTC14 TXNL4A USF1 USO1 VAV2 VDR VIM VPS39 WBP4 ZSCAN1	20 interacting genes: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
Entrez ID		22938	6497
HPRD ID		04340	01271
Ensembl ID		ENSG00000100603	ENSG00000157933
Uniprot IDs		G3V3A4 Q13573	P12755
PDB IDs		5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	1MR1 1SBX 5XOD 6ZVQ
Enriched GO Terms of Interacting Partners?		Nucleoplasm RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Domain Specific Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Cytoplasm Chromatin Binding Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II RNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process MRNA Splicing, Via Spliceosome	Negative Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MiRNA Transcription Chromatin Binding Cellular Developmental Process SMAD Protein Complex Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Cell Population Proliferation
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