SNW1 and KRT40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SNW1	KRT40
Description		SNW domain containing 1	keratin 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Cytosol Cytoskeleton Intermediate Filament Keratin Filament
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Nuclear Vitamin D Receptor Binding Nuclear Retinoic Acid Receptor Binding SMAD Binding Nuclear Androgen Receptor Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		122 interacting genes: ABLIM3 ACTN2 APOBEC3C AR ASCC2 BAG4 BCAS2 BICD2 BYSL C1orf216 CCDC125 CEBPA CEP55 CEP70 CIRSR CPSF7 CSDE1 CTBP1 CWF19L2 DAXX DMRTB1 EP300 ERCC3 EXOSC5 EXOSC7 EXOSC8 FAM90A1 FTSJ3 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT31 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NIN NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OGT OSTF1 PABPN1 PCBD2 PEG10 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBFOX2 RBL1 RBL2 RBM22 RBPJ RBPMS RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 THOC1 TNNT1 TOP1 TRAF1 TRAK1 TRIM15 TRIM23 TRIM55 TRIM63 TSNAXIP1 TTC14 TXNL4A USF1 USO1 VAV2 VDR VIM VPS39 WBP4 ZSCAN1	385 interacting genes: ACSF3 ADAMTS1 ADAMTSL3 AEN AGXT AIRIM AKAP17A ALDH3B1 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATOSA ATPAF2 AVPI1 AXIN1 BAHD1 BARD1 BEX2 BMS1P1 BRME1 BYSL C10orf62 C11orf87 C19orf73 C1orf216 C22orf46P C2orf68 C8orf48 CA6 CARD9 CATIP CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC185 CCDC198 CCDC26 CCDC93 CCER1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CFAP206 CHCHD2 CHCHD3 CHIC2 CLEC18A CNNM3 CNTF COL8A1 COMT COX5A CREB5 CRY2 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DHX57 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 ELOA ENKD1 EXOC3-AS1 FADS2 FAM107A FAM124B FAM27E3 FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FEZF1 FKBP1B FNDC11 FOXB1 FRG1 GAD1 GADD45GIP1 GARIN6 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNE GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAPLN2 HAUS1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB9 HOXC8 HSD3B7 HSF4 HSPA12B HSPD1 ING5 INO80B INPP5D IQUB ISCU ITGB4 ITGB5 JOSD1 KANK2 KAT5 KCTD9 KDM1A KIFC3 KLHL38 KPNA2 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LAGE3 LCE3E LENG1 LHX4 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LNX1 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MID2 MOB3C MOBP MOS MRPL11 MRRF MSRB3 MTA1 MXI1 MYPOP NAB2 NAPRT NEK6 NFKBID NINJ1 NOL4L-DT NPBWR2 NPPB NR1D2 NXF1 ODAD4 OIP5 OPCML OTUB2 PDLIM5 PEX39 PGLS PHF1 PHF21A PHLDA1 PIGS PIMREG PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF18 PRPF31 PSMA1 PSMB1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RGS8 RNF213 RNF6 RPL11 RSPH14 RTP5 RWDD2B RXRB SCAND1 SCNM1 SCOC SEMA4C SETD5 SH2D4A SHC3 SHFL SIRPA SLC23A1 SLC25A10 SLC35D4 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPATA31J1 SPATC1L SPEF1 SPG7 SPMIP2 SRSF2 SSX2 SSX2IP SUOX SYT6 TACO1 TAPBPL TBC1D16 TBC1D21 TBC1D22B TCEA2 TCEANC TCHP TEAD4 THAP7 TIE1 TLE5 TMEM231 TMSB4X TNIP3 TNNT1 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC9C TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT VEZF1 WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZBTB42 ZC2HC1C ZFHX3 ZFP1 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF17 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF319 ZNF329 ZNF337 ZNF408 ZNF410 ZNF417 ZNF438 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF575 ZNF580 ZNF581 ZNF587 ZNF625 ZNF655 ZNF688 ZNF697 ZNF702P ZNF76 ZNF792 ZNF844 ZNRF2P1 ZSCAN21
Entrez ID		22938	125115
HPRD ID		04340	08304
Ensembl ID		ENSG00000100603	ENSG00000204889
Uniprot IDs		G3V3A4 Q13573	G3V1C2 Q6A162
PDB IDs		5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Nucleoplasm RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Domain Specific Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Cytoplasm Chromatin Binding Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II RNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process MRNA Splicing, Via Spliceosome	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Metal Ion Binding DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Carbon Dioxide Transport
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