SCAP and SREBF2

Number of citations of the paper that reports this interaction (PMID 10896675)
10

Data Source:
HPRD (in vitro, in vivo)

		SCAP	SREBF2
Gene Name		SREBF chaperone	sterol regulatory element binding transcription factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding Cholesterol Binding Protein Complex Binding Unfolded Protein Binding	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding
	Biological Process	Response To Hypoxia Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins	Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		22937	6721
HPRD ID		03300	02726
Ensembl ID		ENSG00000114650	ENSG00000198911
Uniprot IDs		F8W921 Q12770	Q12772
PDB IDs			1UKL
Enriched GO Terms of Interacting Partners?		Regulation Of Cargo Loading Into COPII-coated Vesicle Inner Ear Morphogenesis Cholesterol Metabolic Process Ear Morphogenesis Sterol Metabolic Process Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process SREBP Signaling Pathway Response To Sterol Depletion Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Inner Ear Development Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Ear Development Negative Regulation Of Steroid Metabolic Process Middle Ear Morphogenesis Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Embryonic Organ Morphogenesis Alcohol Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Embryonic Organ Development Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Sensory Organ Development Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Embryonic Morphogenesis Neutral Lipid Metabolic Process ER-nucleus Signaling Pathway Palate Development Steroid Biosynthetic Process Bone Morphogenesis Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Small Molecule Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Cellular Lipid Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cochlear Nucleus Development Bone Development Negative Regulation Of Cholesterol Efflux Embryo Development Pulmonary Artery Morphogenesis	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Difference) ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Intersection) ?