SCAP and INSIG2

Number of citations of the paper that reports this interaction (PMID 12242332)
84

Data Source:
HPRD (in vivo, in vitro)

		SCAP	INSIG2
Gene Name		SREBF chaperone	insulin induced gene 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding Cholesterol Binding Protein Complex Binding Unfolded Protein Binding	Protein Binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Response To Fatty Acid
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins	Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS			Bone mineral density ( 22504420)
Protein-Protein Interactions		5 interactors: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	8 interactors: PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP
Entrez ID		22937	51141
HPRD ID		03300	16361
Ensembl ID		ENSG00000114650	ENSG00000125629
Uniprot IDs		F8W921 Q12770	B4DQ23 Q9Y5U4
PDB IDs			4J82
Enriched GO Terms of Interacting Partners?		Regulation Of Cargo Loading Into COPII-coated Vesicle Inner Ear Morphogenesis Cholesterol Metabolic Process Ear Morphogenesis Sterol Metabolic Process Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process SREBP Signaling Pathway Response To Sterol Depletion Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Inner Ear Development Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Ear Development Negative Regulation Of Steroid Metabolic Process Middle Ear Morphogenesis Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Embryonic Organ Morphogenesis Alcohol Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Embryonic Organ Development Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Sensory Organ Development Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Embryonic Morphogenesis Neutral Lipid Metabolic Process ER-nucleus Signaling Pathway Palate Development Steroid Biosynthetic Process Bone Morphogenesis Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Small Molecule Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Cellular Lipid Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cochlear Nucleus Development Bone Development Negative Regulation Of Cholesterol Efflux Embryo Development Pulmonary Artery Morphogenesis	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Protein Ubiquitination Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Protein Modification By Small Protein Conjugation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Proteolysis Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scap scavenger ser srebp sterol unresponsive
Tagcloud (Difference) ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	1alpha ampkalpha anchor atherosclerotic cd36 cholesterol coa coactivator deacetylation escort hexarelin hmg lifted peroxisome pgc pgc1alpha ppargamma ppargamma1 proliferator reductase revealing scavenger ser srebp sterol unresponsive
Tagcloud (Intersection) ?		scap