SCAP and PGRMC1

Number of citations of the paper that reports this interaction (PMID 15782218)
49

Data Source:
HPRD (in vivo)

		SCAP	PGRMC1
Gene Name		SREBF chaperone	progesterone receptor membrane component 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Cholesterol Binding Protein Complex Binding Unfolded Protein Binding	Steroid Binding Protein Binding Heme Binding
	Biological Process	Response To Hypoxia Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process	Axon Guidance
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	5 interactors: CENPU CREB3L1 MTNR1A PAM16 SCAP
Entrez ID		22937	10857
HPRD ID		03300	02338
Ensembl ID		ENSG00000114650	ENSG00000101856
Uniprot IDs		F8W921 Q12770	O00264 Q6IB11
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cargo Loading Into COPII-coated Vesicle Inner Ear Morphogenesis Cholesterol Metabolic Process Ear Morphogenesis Sterol Metabolic Process Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process SREBP Signaling Pathway Response To Sterol Depletion Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Inner Ear Development Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Ear Development Negative Regulation Of Steroid Metabolic Process Middle Ear Morphogenesis Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Embryonic Organ Morphogenesis Alcohol Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Embryonic Organ Development Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Sensory Organ Development Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Embryonic Morphogenesis Neutral Lipid Metabolic Process ER-nucleus Signaling Pathway Palate Development Steroid Biosynthetic Process Bone Morphogenesis Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Small Molecule Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Cellular Lipid Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cochlear Nucleus Development Bone Development Negative Regulation Of Cholesterol Efflux Embryo Development Pulmonary Artery Morphogenesis	ER-nucleus Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Protein Import Into Mitochondrial Matrix Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of ATPase Activity Positive Regulation Of Receptor Biosynthetic Process Response To Sterol Depletion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Receptor Biosynthetic Process Positive Regulation Of CGMP Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Regulation Of CGMP Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process CENP-A Containing Nucleosome Assembly Regulation Of Cholesterol Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of CGMP Metabolic Process Histone Exchange Mating Behavior DNA Replication-independent Nucleosome Assembly Regulation Of Nitrogen Compound Metabolic Process Regulation Of ATPase Activity Negative Regulation Of Lipid Biosynthetic Process Centromere Complex Assembly Intracellular Protein Transmembrane Transport Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	abeta25 ag205 alleviated attempted attenuate attenuates brings broadly classic complementary entitled exerts inhibiting insults jnk mitochondria nervous neuroprotection neuroprotections neuroprotective neurosteroid pr progesterone protected protective rescuing ru486 special steroids
Tagcloud (Difference) ?		acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous	abeta25 ag205 alleviated attempted attenuate attenuates brings broadly classic complementary entitled exerts inhibiting insults jnk mitochondria nervous neuroprotection neuroprotections neuroprotective neurosteroid pr progesterone protected protective rescuing ru486 special steroids
Tagcloud (Intersection) ?