SACM1L and COPA

Number of citations of the paper that reports this interaction (PMID 14527956)
27

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SACM1L	COPA
Gene Name		SAC1 suppressor of actin mutations 1-like (yeast)	coatomer protein complex, subunit alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex	Extracellular Space Cytoplasm Cytosol Membrane COPI Vesicle Coat Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Binding Phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity	Hormone Activity Structural Molecule Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Pancreatic Juice Secretion COPI Coating Of Golgi Vesicle Membrane Organization
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the ER membrane Phospholipid metabolism PI Metabolism	COPI Mediated Transport Golgi to ER Retrograde Transport
Drugs
Diseases
GWAS		Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		4 interactors: COPA COPB2 COPG1 PRKCA	12 interactors: ARCN1 ARFGAP1 COPB2 COPE COPZ1 MTNR1B PDGFRB SACM1L SLC25A11 STX8 TMED10 TMED2
Entrez ID		22908	1314
HPRD ID		07587	03564
Ensembl ID		ENSG00000211456	ENSG00000122218
Uniprot IDs		B4DK71 Q9NTJ5	P53621
PDB IDs
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Membrane Budding Membrane Organization Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Organelle Localization Positive Regulation Of Dense Core Granule Biogenesis Intracellular Protein Transport Histone H3-T6 Phosphorylation Organelle Organization Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Peptidyl-serine Autophosphorylation Establishment Of Golgi Localization Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Pancreatic Juice Secretion Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Protein Localization Desmosome Organization Establishment Of Localization In Cell Golgi Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Cellular Localization Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Membrane Budding Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Organization Establishment Of Vesicle Localization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Intracellular Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Cellular Protein Localization Organelle Organization Intra-Golgi Vesicle-mediated Transport Cellular Localization Cargo Loading Into Vesicle ER To Golgi Vesicle-mediated Transport COPII Vesicle Coating COPII-coated Vesicle Budding Transport Cytoplasmic Transport Cell Migration Involved In Coronary Angiogenesis Cerebellar Purkinje Cell Layer Maturation Metanephric Mesenchymal Cell Migration Golgi Organization Angiogenesis Involved In Coronary Vascular Morphogenesis Cell Migration Involved In Kidney Development Alpha-ketoglutarate Transport Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Smooth Muscle Cell Chemotaxis Cerebellum Maturation Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Cell Migration Involved In Vasculogenesis Metanephric S-shaped Body Morphogenesis Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Mesenchymal Cell Migration Comma-shaped Body Morphogenesis
Tagcloud ?		4b adriamycin ataxia carboplatin coded ct cyclophosphamide desirable eif4b isoaspartate matr3 matrin meiotic microrchidia morc3 pbl pbls pcmtd2 pdcd10 personalised psmb1 rmnd5a runt runx2 subtraction telangiectasia tmem66 undesired znf644	atpases cgr cognate copb copper copz copz1 copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur
Tagcloud (Difference) ?		4b adriamycin ataxia carboplatin coded ct cyclophosphamide desirable eif4b isoaspartate matr3 matrin meiotic microrchidia morc3 pbl pbls pcmtd2 pdcd10 personalised psmb1 rmnd5a runt runx2 subtraction telangiectasia tmem66 undesired znf644	atpases cgr cognate copb copper copz copz1 copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur
Tagcloud (Intersection) ?