SACM1L and MTERF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SACM1L	MTERF2
Description		SAC1 like phosphatidylinositide phosphatase	mitochondrial transcription termination factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse Endoplasmic Reticulum-plasma Membrane Contact Site	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity	Nucleic Acid Binding DNA Binding Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Termination Of Mitochondrial Transcription
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FAM209A FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35H1 SLC71A2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27	3 interacting genes: APOD SACM1L STX6
Entrez ID		22908	80298
HPRD ID		07587	17431
Ensembl ID		ENSG00000211456	ENSG00000120832
Uniprot IDs		A0A5F9ZHN7 A0A9L9PXJ6 B4DVV3 E9PGZ4 Q9NTJ5	Q49AM1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane COPI Vesicle Coat COPI-coated Vesicle Membrane Endoplasmic Reticulum Membrane Coat Intra-Golgi Vesicle-mediated Transport Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Tubular Network Formation Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Organization Golgi Membrane Structural Molecule Activity Sodium Ion Transport Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Synaptic Vesicle To Endosome Fusion Phosphatidylinositol-4-phosphate Phosphatase Activity Regulation Of Smooth Muscle Cell-matrix Adhesion Phosphatidylinositol Phosphate 4-phosphatase Activity Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Endoplasmic Reticulum-plasma Membrane Contact Site Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Negative Regulation Of Lymphocyte Migration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Focal Adhesion Assembly Perinuclear Region Of Cytoplasm Negative Regulation Of Chemokine Production Lipid Transporter Activity Neuron Projection Regeneration Axon Regeneration Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Membrane Phosphatidylinositol Dephosphorylation AMPA Glutamate Receptor Complex Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Mononuclear Cell Migration SNAP Receptor Activity Phospholipid Dephosphorylation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Localization To Nucleus Response To Axon Injury Cholesterol Binding Regulation Of T Cell Migration Negative Regulation Of Cytokine Production Involved In Inflammatory Response Tissue Regeneration Regulation Of Protein Localization SNARE Complex Syntaxin Binding Organelle Membrane Axon Development Negative Regulation Of Leukocyte Migration Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Intracellular Transport Lipid Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell-substrate Adhesion
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