SACM1L and ZFYVE27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SACM1L	ZFYVE27
Description		SAC1 like phosphatidylinositide phosphatase	zinc finger FYVE-type containing 27
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse Endoplasmic Reticulum-plasma Membrane Contact Site	Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Membrane Axon Dendrite Growth Cone Membrane Cell Projection Recycling Endosome Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Axon Extension Neurotrophin TRK Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Protein Localization To Plasma Membrane
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FAM209A FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35H1 SLC71A2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27	18 interacting genes: APP GIMAP1 GIMAP5 IER3IP1 ORMDL1 OTOP3 PIP4P2 SACM1L SEC22A SLC30A8 SLC66A2 STX7 TMEM128 TMEM14C TMEM243 TMEM65 TSPAN2 YIF1A
Entrez ID		22908	118813
HPRD ID		07587	15735
Ensembl ID		ENSG00000211456	ENSG00000155256
Uniprot IDs		A0A5F9ZHN7 A0A9L9PXJ6 B4DVV3 E9PGZ4 Q9NTJ5	A0A0S2Z5V0 A0A0S2Z627 B7Z6J9 Q5T4F4
PDB IDs			1X4U
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane COPI Vesicle Coat COPI-coated Vesicle Membrane Endoplasmic Reticulum Membrane Coat Intra-Golgi Vesicle-mediated Transport Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Tubular Network Formation Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Organization Golgi Membrane Structural Molecule Activity Sodium Ion Transport Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Membrane Microglia Development Intracellular Transport Vesicle-mediated Transport Insulin Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Dephosphorylation Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell SNAP Receptor Activity Golgi Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Phospholipid Dephosphorylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Endosome Amylin Binding Positive Regulation Of Toll Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?