SACM1L and DHRS7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SACM1L	DHRS7
Description		SAC1 like phosphatidylinositide phosphatase	dehydrogenase/reductase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse Endoplasmic Reticulum-plasma Membrane Contact Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Retinol Metabolic Process
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic rhinitis ( 22036096) Optic disc size ( 31809533)
Interacting Genes		36 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FAM209A FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35H1 SLC71A2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27	4 interacting genes: ETV5 GLP1R HRH1 SACM1L
Entrez ID		22908	51635
HPRD ID		07587	16802
Ensembl ID		ENSG00000211456	ENSG00000100612
Uniprot IDs		A0A5F9ZHN7 A0A9L9PXJ6 B4DVV3 E9PGZ4 Q9NTJ5	Q9Y394
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane COPI Vesicle Coat COPI-coated Vesicle Membrane Endoplasmic Reticulum Membrane Coat Intra-Golgi Vesicle-mediated Transport Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Tubular Network Formation Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Organization Golgi Membrane Structural Molecule Activity Sodium Ion Transport Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Male Germ-line Stem Cell Asymmetric Division Chemical Synaptic Transmission Response To Psychosocial Stress Regulation Of Blood Circulation Learning Or Memory Post-translational Protein Targeting To Membrane, Translocation Cognition Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Cellular Response To Histamine Phospholipase C-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Endoplasmic Reticulum-plasma Membrane Contact Site Trans-synaptic Signaling Synaptic Signaling Cellular Response To Glucagon Stimulus Response To Histamine G Protein-coupled Receptor Activity Asymmetric Cell Division Secretion By Cell Activation Of Adenylate Cyclase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Response To Glucagon G Protein-coupled Serotonin Receptor Signaling Pathway Secretion Positive Regulation Of Cyclase Activity Stem Cell Division Positive Regulation Of Glial Cell Proliferation Phosphatidylinositol Dephosphorylation Regulation Of System Process Positive Regulation Of Vasoconstriction AMPA Glutamate Receptor Complex Cell-cell Signaling Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Neuromuscular Synaptic Transmission Signaling Cell Communication Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Phospholipid Dephosphorylation Regulation Of Glial Cell Proliferation
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