PAWR

Description		pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SQSTM1 TFPT THAP1 WT1
Entrez ID		5074
HPRD ID		09051
Ensembl ID		ENSG00000177425
Uniprot IDs		Q96IZ0
PDB IDs		2JK9
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leucine Zipper Domain Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Morphogenesis Of A Branching Structure Ionotropic Glutamate Receptor Binding Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of RNA Metabolic Process Temperature Homeostasis Negative Regulation Of Translation Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Programmed Cell Death Maintenance Of Protein Localization In Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Choline:sodium Symporter Activity Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Cell Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of DNA-templated Transcription Protein Catabolic Process Cerebellum Structural Organization Maintenance Of Protein Location Maintenance Of Location In Cell Positive Regulation Of Telomere Maintenance Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development
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