PAWR and SLC5A7

Number of citations of the paper that reports this interaction (PubMedID 15090548)
0

Data Source:
HPRD (in vivo, in vitro)

		PAWR	SLC5A7
Description		pro-apoptotic WT1 regulator	solute carrier family 5 member 7
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton	Endosome Plasma Membrane Membrane Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Neuronal Cell Body Perikaryon Synapse Presynapse
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	Choline:sodium Symporter Activity Choline Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity Choline Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence	In Utero Embryonic Development Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process Choline Transport Transmembrane Transport
Pathways			Acetylcholine Neurotransmitter Release Cycle Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC-mediated bile acid transport
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SQSTM1 TFPT THAP1 WT1	2 interacting genes: PAWR SNCA
Entrez ID		5074	60482
HPRD ID		09051	12294
Ensembl ID		ENSG00000177425	ENSG00000115665
Uniprot IDs		Q96IZ0	B2RCU2 B4DUU7 Q2T9H3 Q9GZV3
PDB IDs		2JK9	8J74 8J75 8J76 8J77 8ZQO 8ZQP 8ZQQ 8ZQR 9BFI 9BFJ 9BFK 9BIM
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leucine Zipper Domain Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Morphogenesis Of A Branching Structure Ionotropic Glutamate Receptor Binding Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of RNA Metabolic Process Temperature Homeostasis Negative Regulation Of Translation Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Programmed Cell Death Maintenance Of Protein Localization In Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Choline:sodium Symporter Activity Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Cell Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of DNA-templated Transcription Protein Catabolic Process Cerebellum Structural Organization Maintenance Of Protein Location Maintenance Of Location In Cell Positive Regulation Of Telomere Maintenance Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Enzyme Binding Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Actin Binding Actin Cytoskeleton Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Supramolecular Fiber Organization Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Leucine Zipper Domain Binding Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Cell Activation SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Positive Regulation Of Receptor Recycling Positive Regulation Of Glycoprotein Metabolic Process Negative Regulation Of B Cell Proliferation Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Cellular Senescence Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process
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