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PAWR and WT1
Number of citations of the paper that reports this interaction (PubMedID
8943350
)
65
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo, two hybrid)
PAWR
WT1
Description
pro-apoptotic WT1 regulator
WT1 transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Actin Cytoskeleton
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
Transcription Corepressor Activity
Actin Binding
Protein Binding
Enzyme Binding
Leucine Zipper Domain Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of B Cell Proliferation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Fibroblast Proliferation
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Apoptotic Signaling Pathway
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Positive Regulation Of Cellular Senescence
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Nephron Tubule Morphogenesis
Podocyte Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Circulatory System Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
Transcriptional regulation of testis differentiation
Negative Regulation of CDH1 Gene Transcription
Nephron development
Drugs
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Brain morphology (MOSTest) (
32665545
)
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Brugada syndrome (
35210625
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31649266
31249589
30194396
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
14 interacting genes:
AATF
ATP5F1C
DAPK3
DRD2
HSPA5
PML
PRKCZ
RRAS2
SLC5A7
SPSB1
SQSTM1
TFPT
THAP1
WT1
66 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OGT
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
YAP1
ZNF205
ZRANB1
Entrez ID
5074
7490
HPRD ID
09051
06163
Ensembl ID
ENSG00000177425
ENSG00000184937
Uniprot IDs
Q96IZ0
A0A481V744
H0Y7K5
P19544
Q6PI38
PDB IDs
2JK9
1XF7
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
6WLH
7BBG
8ISN
Enriched GO Terms of Interacting Partners
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PML Body
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Leucine Zipper Domain Binding
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle
Regulation Of DNA-templated Transcription
Regulation Of Cellular Component Organization
Intracellular Signal Transduction
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Synaptic Transmission
Morphogenesis Of A Branching Structure
Ionotropic Glutamate Receptor Binding
Response To Interleukin-4
Cellular Response To Interleukin-4
Regulation Of RNA Metabolic Process
Temperature Homeostasis
Negative Regulation Of Translation
Regulation Of Synaptic Plasticity
Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Programmed Cell Death
Maintenance Of Protein Localization In Organelle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Myosin II Filament Organization
Regulation Of Protein Metabolic Process
Regulation Of Cellular Response To Stress
Regulation Of Protein Folding In Endoplasmic Reticulum
Negative Regulation Of Translation In Response To Oxidative Stress
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Choline:sodium Symporter Activity
Regulation Of Macromolecule Biosynthetic Process
Maintenance Of Protein Location In Cell
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Circadian Regulation Of Gene Expression
G Protein-coupled Receptor Complex
Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production
Positive Regulation Of DNA-templated Transcription
Protein Catabolic Process
Cerebellum Structural Organization
Maintenance Of Protein Location
Maintenance Of Location In Cell
Positive Regulation Of Telomere Maintenance
Adrenal Cortex Formation
Positive Regulation Of Metanephric Ureteric Bud Development
Visceral Serous Pericardium Development
Keratin Filament
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Intermediate Filament
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
P53 Binding
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Macromolecule Metabolic Process
Transcription Cis-regulatory Region Binding
Nuclear Body
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Cellular Response To Gamma Radiation
Cellular Response To Radiation
Chromatin
Identical Protein Binding
Epithelial Cell Proliferation
Regulation Of Stem Cell Population Maintenance
Regulation Of Somatic Stem Cell Population Maintenance
MDM2/MDM4 Family Protein Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Cellular Response To UV
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Actinomycin D
Cell Population Proliferation
Positive Regulation Of Lymphocyte Apoptotic Process
Nucleus
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Signal Transduction By P53 Class Mediator
Response To Gamma Radiation
Transcription Factor Binding
Regulation Of Metabolic Process
Regulation Of Signal Transduction
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of MiRNA Transcription
Cytosol
Cellular Response To Light Stimulus
Response To Actinomycin D
PML Body
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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