RAPGEF4 and BZRAP1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		RAPGEF4	BZRAP1
Gene Name		Rap guanine nucleotide exchange factor (GEF) 4	benzodiazepine receptor (peripheral) associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Ras GTPase Binding CAMP Binding	Protein Binding Benzodiazepine Receptor Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Platelet Activation Positive Regulation Of Ras GTPase Activity Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion	Synaptic Transmission Neurotransmitter Secretion Biological_process Glutamate Secretion
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ATXN1 BZRAP1 C16orf45 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 ZC3H11A	19 interactors: ANKRD11 ARNT2 BEND5 CACNA1A CADPS2 CEP76 DISC1 DLGAP2 DLX2 GPRASP2 KHDRBS1 KIF1A MVP NDE1 RAPGEF4 REL TCF4 TSC22D4 TSPO
Entrez ID		11069	9256
HPRD ID		06929	09832
Ensembl ID		ENSG00000091428	ENSG00000005379
Uniprot IDs		B7Z283 Q8WZA2	A7E2C5 B2RUT8 B7ZVZ7 O95153
PDB IDs
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Intracellular Signal Transduction Neurotransmitter Secretion Membrane Depolarization Nuclear Export Regulation Of Neurotransmitter Levels Synaptic Transmission Regulation Of Phosphorylation Regulation Of Cell Migration Regulation Of Exocytosis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of JNK Cascade Regulation Of Cell Motility Neurotransmitter Transport Regulation Of Secretion Cellular Localization Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Regulation Of Neurogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Phosphorylation Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Motility Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Cellular Component Movement	Head Development Cell Proliferation Brain Development Negative Regulation Of Biosynthetic Process Central Nervous System Development Negative Regulation Of Cellular Metabolic Process Regulation Of Gliogenesis Odontogenesis Of Dentin-containing Tooth G2/M Transition Of Mitotic Cell Cycle Regulation Of Neurogenesis Behavioral Response To Pain Cellular Localization Odontogenesis Energy Reserve Metabolic Process Regulation Of Exocytosis Protein Localization Forebrain Development Regulation Of Cell Development Establishment Of Localization In Cell Regulation Of Hormone Metabolic Process Face Morphogenesis Cell-cell Signaling Response To Pain Signaling Regulation Of Insulin Secretion Pallium Development Head Morphogenesis Vesicle Localization Cell Communication Calcium Ion-dependent Exocytosis Regulation Of Peptide Hormone Secretion Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Organ Development Nervous System Development Regulation Of Cellular Localization Regulation Of Signaling Face Development Synaptic Transmission Neurogenesis Negative Regulation Of Transcription, DNA-templated Cerebellar Molecular Layer Development Mitotic Cell Cycle Phase Transition Regulation Of Hormone Secretion Cell Cycle Phase Transition Negative Regulation Of Nucleic Acid-templated Transcription Body Morphogenesis Negative Regulation Of RNA Biosynthetic Process Regulation Of Secretion Telencephalon Development
Tagcloud ?		adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Difference) ?		adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Intersection) ?