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RAPGEF4 and RRAS2
Number of citations of the paper that reports this interaction (PMID
12384139
)
34
Data Source:
HPRD
(in vitro)
RAPGEF4
RRAS2
Gene Name
Rap guanine nucleotide exchange factor (GEF) 4
related RAS viral (r-ras) oncogene homolog 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Membrane
Endoplasmic Reticulum
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Vesicular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Ras Guanyl-nucleotide Exchange Factor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Ras GTPase Binding
CAMP Binding
GTPase Activity
Protein Binding
GTP Binding
Biological Process
Energy Reserve Metabolic Process
G-protein Coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Blood Coagulation
Calcium Ion-dependent Exocytosis
Regulation Of Exocytosis
CAMP-mediated Signaling
Insulin Secretion
Platelet Activation
Positive Regulation Of Ras GTPase Activity
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Insulin Secretion
Osteoblast Differentiation
Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
Regulation Of Neuron Death
Pathways
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Integration of energy metabolism
Regulation of insulin secretion
Integrin alphaIIb beta3 signaling
Platelet activation, signaling and aggregation
Platelet Aggregation (Plug Formation)
Adaptive Immune System
Drugs
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Protein-Protein Interactions
11 interactors:
ATXN1
BZRAP1
C16orf45
MAP1A
RAP1A
RAP2A
RIMS2
RRAS2
SWAP70
TRAF2
ZC3H11A
29 interactors:
ACVR1
AHSG
ARAF
ARHGEF2
BMPR1B
CREB3
FNTB
LGALS4
MLLT4
PAWR
PGGT1B
PIK3R1
PTPN1
RABAC1
RAF1
RALGDS
RAPGEF1
RAPGEF3
RAPGEF4
RASGRF1
RASIP1
RASSF5
RIN1
SMAD3
SMAD4
SMURF2
TRAF2
TRAF3
XRCC6
Entrez ID
11069
22800
HPRD ID
06929
02518
Ensembl ID
ENSG00000091428
ENSG00000133818
Uniprot IDs
B7Z283
Q8WZA2
B7Z5Z2
P62070
PDB IDs
2ERY
Enriched GO Terms of Interacting Partners
?
Rap Protein Signal Transduction
Ras Protein Signal Transduction
Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Postsynaptic Membrane Potential
Intracellular Signal Transduction
Neurotransmitter Secretion
Membrane Depolarization
Nuclear Export
Regulation Of Neurotransmitter Levels
Synaptic Transmission
Regulation Of Phosphorylation
Regulation Of Cell Migration
Regulation Of Exocytosis
Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Regulation Of MAPK Cascade
Small GTPase Mediated Signal Transduction
Regulation Of JNK Cascade
Regulation Of Cell Motility
Neurotransmitter Transport
Regulation Of Secretion
Cellular Localization
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Stress-activated MAPK Cascade
Regulation Of Locomotion
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Component Movement
Regulation Of Neurogenesis
Negative Regulation Of Cell Migration
Positive Regulation Of Protein Phosphorylation
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Motility
Positive Regulation Of Protein Homodimerization Activity
Negative Regulation Of Cellular Component Movement
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Signal Transduction
Response To Stimulus
Signaling
Cell Communication
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Intracellular Signal Transduction
Regulation Of Phosphorylation
Regulation Of Catalytic Activity
Response To Organic Substance
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Hydrolase Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Phosphorylation
Response To Growth Factor
Regulation Of Intracellular Signal Transduction
Endothelial Cell Differentiation
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Endothelium Development
Regulation Of Cellular Protein Metabolic Process
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cellular Process
Regulation Of GTPase Activity
Response To Stress
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Regulation Of Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Proliferation
Negative Regulation Of Signaling
Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Cell Proliferation
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Death
Positive Regulation Of Rap GTPase Activity
Positive Regulation Of GTPase Activity
Regulation Of Bone Mineralization
Defense Response
BMP Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Ras GTPase Activity
Regulation Of Protein Localization
Tagcloud
?
adenylyl
analog
calr
calreticulin
camp
chlorophenylthio
cox2
cpt
cyclase
cyclooxygenase
em1
endometrial
epac
epac2
establishment
forskolin
galactosidase
glands
glandular
implantation
lif
pge2
phe
pka
prostaglandin
ptgs2
receptivity
silenced
uterine
Tagcloud (Difference)
?
adenylyl
analog
calr
calreticulin
camp
chlorophenylthio
cox2
cpt
cyclase
cyclooxygenase
em1
endometrial
epac
epac2
establishment
forskolin
galactosidase
glands
glandular
implantation
lif
pge2
phe
pka
prostaglandin
ptgs2
receptivity
silenced
uterine
Tagcloud (Intersection)
?