RAPGEF4 and ZC3H11A

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		RAPGEF4	ZC3H11A
Description		Rap guanine nucleotide exchange factor 4	zinc finger CCCH-type containing 11A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Transcription Export Complex Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Exocytosis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Hormone Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	Poly(A)+ MRNA Export From Nucleus MRNA Transport
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting blood glucose ( 33842983) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)	Breast cancer ( 25038754) Male-pattern baldness ( 28196072)
Interacting Genes		14 interacting genes: ATXN1 BMERB1 DEF6 DSCAM LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	11 interacting genes: CEBPA MIR141 MIR214 MIR9-1 MIR9-2 MLH1 MTNR1A RAPGEF4 RNF10 SMARCB1 SUMO2
Entrez ID		11069	9877
HPRD ID		06929	11100
Ensembl ID		ENSG00000091428	ENSG00000058673
Uniprot IDs		B7Z278 E9PB94 Q8WZA2 X5D7N4	O75152
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission GDP Binding Rap Protein Signal Transduction Regulation Of Cell Communication Regulation Of Protein Depolymerization Regulation Of Signaling Small GTPase-mediated Signal Transduction Cellular Localization GTPase Activity Regulation Of Locomotion Regulation Of Protein-containing Complex Disassembly Regulation Of Regulated Secretory Pathway Regulation Of Glial Cell Migration GTP Binding Cell Projection Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Regulation Of Biological Quality Regulation Of Microtubule Depolymerization Regulation Of Exocytosis Intracellular Signaling Cassette Locomotory Behavior Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Locomotion Cell Projection Morphogenesis Netrin Receptor Binding Positive Regulation Of Phosphorylation Social Behavior Neuron Projection Morphogenesis Synapse Synapse Organization Tubulin Binding Retrograde Axonal Protein Transport Primary Dendrite Establishment Of Localization In Cell Neuron Cellular Homeostasis Regulation Of Signal Transduction Small GTPase Binding Response To Antineoplastic Agent Guanyl-nucleotide Exchange Factor Activity Regulation Of MAPK Cascade Regulation Of Secretion Regulation Of Secretion By Cell G Protein Activity Nuclear Transport	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Regulation Of Osteoblast Differentiation Negative Regulation Of Translation Regulation Of Cell Population Proliferation Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Hippocampal Mossy Fiber To CA3 Synapse Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Negative Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Biosynthetic Process CHOP-C/EBP Complex Positive Regulation Of Cell Activation Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Developmental Process Male Meiosis Chromosome Segregation MutLalpha Complex Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Regulation Of Transformation Of Host Cell By Virus
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