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RAPGEF4 and RIMS2
Number of citations of the paper that reports this interaction (PMID
11598134
)
78
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
RAPGEF4
RIMS2
Gene Name
Rap guanine nucleotide exchange factor (GEF) 4
regulating synaptic membrane exocytosis 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Membrane
Cell Junction
Presynaptic Membrane
Presynaptic Active Zone
Extracellular Vesicular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Ras Guanyl-nucleotide Exchange Factor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Ras GTPase Binding
CAMP Binding
Protein Binding
Rab GTPase Binding
Ion Channel Binding
Metal Ion Binding
Biological Process
Energy Reserve Metabolic Process
G-protein Coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Blood Coagulation
Calcium Ion-dependent Exocytosis
Regulation Of Exocytosis
CAMP-mediated Signaling
Insulin Secretion
Platelet Activation
Positive Regulation Of Ras GTPase Activity
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Insulin Secretion
Intracellular Protein Transport
Positive Regulation Of Gene Expression
Calcium Ion-dependent Exocytosis
Regulation Of Exocytosis
CAMP-mediated Signaling
Insulin Secretion
Regulation Of Membrane Potential
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Integration of energy metabolism
Regulation of insulin secretion
Integrin alphaIIb beta3 signaling
Platelet activation, signaling and aggregation
Platelet Aggregation (Plug Formation)
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
ATXN1
BZRAP1
C16orf45
MAP1A
RAP1A
RAP2A
RIMS2
RRAS2
SWAP70
TRAF2
ZC3H11A
12 interactors:
ABCA1
CACNA1S
RAB27A
RAB3A
RAB3B
RAB3C
RAB3D
RAB8A
RABAC1
RAPGEF4
RPH3AL
YWHAH
Entrez ID
11069
9699
HPRD ID
06929
09436
Ensembl ID
ENSG00000091428
Uniprot IDs
B7Z283
Q8WZA2
Q9UQ26
PDB IDs
1V27
1WFG
Enriched GO Terms of Interacting Partners
?
Rap Protein Signal Transduction
Ras Protein Signal Transduction
Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Postsynaptic Membrane Potential
Intracellular Signal Transduction
Neurotransmitter Secretion
Membrane Depolarization
Nuclear Export
Regulation Of Neurotransmitter Levels
Synaptic Transmission
Regulation Of Phosphorylation
Regulation Of Cell Migration
Regulation Of Exocytosis
Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Regulation Of MAPK Cascade
Small GTPase Mediated Signal Transduction
Regulation Of JNK Cascade
Regulation Of Cell Motility
Neurotransmitter Transport
Regulation Of Secretion
Cellular Localization
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Stress-activated MAPK Cascade
Regulation Of Locomotion
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Component Movement
Regulation Of Neurogenesis
Negative Regulation Of Cell Migration
Positive Regulation Of Protein Phosphorylation
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Motility
Positive Regulation Of Protein Homodimerization Activity
Negative Regulation Of Cellular Component Movement
Protein Secretion
Regulation Of Exocytosis
Secretion By Cell
Rab Protein Signal Transduction
Vesicle Docking Involved In Exocytosis
Exocytosis
Secretion
Regulation Of Vesicle-mediated Transport
Vesicle Docking
Membrane Docking
Synaptic Vesicle Transport
Protein Transport
Establishment Of Protein Localization
Synaptic Vesicle Exocytosis
Regulation Of Cellular Localization
Regulation Of Secretion
Protein Localization
Establishment Of Vesicle Localization
Vesicle Localization
Establishment Of Localization In Cell
Ras Protein Signal Transduction
Vesicle-mediated Transport
Intracellular Protein Transport
Neurotransmitter Secretion
Intracellular Transport
Cellular Localization
Small GTPase Mediated Signal Transduction
Establishment Of Organelle Localization
Regulation Of Neurotransmitter Levels
Neurotransmitter Transport
Positive Regulation Of Transport
Organelle Localization
Cellular Protein Localization
Cell-cell Signaling
Transport
Positive Regulation Of Regulated Secretory Pathway
Synaptic Transmission
Intracellular Signal Transduction
Peptidyl-cysteine Methylation
Regulation Of Regulated Secretory Pathway
Positive Regulation Of Exocytosis
Regulation Of Synaptic Transmission
Response To Stimulus
Positive Regulation Of Secretion
Endomembrane System Organization
Signal Transduction
Regulation Of Synaptic Plasticity
Signaling
Cell Communication
Vesicle Organization
Tagcloud
?
adenylyl
analog
calr
calreticulin
camp
chlorophenylthio
cox2
cpt
cyclase
cyclooxygenase
em1
endometrial
epac
epac2
establishment
forskolin
galactosidase
glands
glandular
implantation
lif
pge2
phe
pka
prostaglandin
ptgs2
receptivity
silenced
uterine
Tagcloud (Difference)
?
adenylyl
analog
calr
calreticulin
camp
chlorophenylthio
cox2
cpt
cyclase
cyclooxygenase
em1
endometrial
epac
epac2
establishment
forskolin
galactosidase
glands
glandular
implantation
lif
pge2
phe
pka
prostaglandin
ptgs2
receptivity
silenced
uterine
Tagcloud (Intersection)
?