FCGR2A and TARDBP

		FCGR2A	TARDBP
Description		Fc gamma receptor IIa	TAR DNA binding protein
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule
	Molecular Function	Protein Binding IgG Receptor Activity IgG Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity
	Biological Process	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases		Systemic lupus erythematosus	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)	Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)
Interacting Genes		26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2	18 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1
Entrez ID		2212	23435
HPRD ID		00906	05466
Ensembl ID		ENSG00000143226	ENSG00000120948
Uniprot IDs		A0A8V8TPS4 P12318	Q13148 Q9H256
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA	1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity	Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity
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