FBP1 and HSPA8

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid, affinity chromatography technology), HPRD (two hybrid)

		FBP1	HSPA8
Name		fructose-bisphosphatase 1	heat shock protein family A (Hsp70) member 8
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Secretory Granule Lumen Melanosome Lysosomal Lumen Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Catalytic Activity Protein Binding AMP Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding G Protein-coupled Receptor Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Response To Nutrient Levels Cellular Response To Insulin Stimulus Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Hyperosmotic Salinity Response Cellular Hypotonic Salinity Response Cellular Response To Raffinose Cellular Response To Phorbol 13-acetate 12-myristate	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding Autophagy Response To Unfolded Protein Signal Transduction RNA Splicing Cellular Response To Starvation Negative Regulation Of Signal Transduction Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Protein Stability Cellular Response To Stress Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Refolding Regulation Of Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription ATP Metabolic Process Negative Regulation Of Cellular Component Organization Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Cellular Response To Steroid Hormone Stimulus Clathrin Coat Disassembly Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly
Pathways		Gluconeogenesis	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy Respiratory syncytial virus genome transcription PKR-mediated signaling
Drugs		Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE	Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases		Fructose-1,6-bisphosphatase deficiency	None
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Colorectal or endometrial cancer ( 26621817 ) Obesity-related traits ( 23251661 )	Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 32888494 ) Postoperative acute renal failure after cardiac surgery ( 30678657 ) Red cell distribution width ( 32888494 ) Serum metabolite levels ( 33031748 )
Interacting Genes		40 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DNMT1 DYNC1I1 ERBB2 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 NOTCH1 PCNX4 PIM2 POT1 PRKN PTK2 PTPRJ RB1 RELA RNF183 STK11 TERF1 TLR2 TRIM28	92 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DPP3 DYNLL1 EGFR ERBB3 ERH ESR1 FANCC FBP1 FNDC3B FOXP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT NEDD8 NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 RNF26 SAYSD1 SIRPA SNCA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 USP40 VHL WEE2-AS1 YWHAG YWHAQ
Entrez ID		2203	3312
HPRD ID		01973	07205
Ensembl ID		ENSG00000165140	ENSG00000109971
Uniprot IDs		P09467 Q2TU34	P11142 Q53HF2 V9HW22
PDB IDs		1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB 8XBK	3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N 6ZYJ
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Nervous System Development Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nervous System Development Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Anatomical Structure Morphogenesis Positive Regulation Of Catabolic Process Regulation Of Phosphorylation Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Neurogenesis Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Positive Regulation Of Neurogenesis Programmed Cell Death Regulation Of Growth Cell Death	Ubiquitin Protein Ligase Binding Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Folding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Apoptotic Process Enzyme Binding Response To Stress Negative Regulation Of Programmed Cell Death Cytosol Apoptotic Process Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Cell Death Positive Regulation Of Programmed Cell Death Adenyl-nucleotide Exchange Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Protein Modification Process Heat Shock Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Hsp70 Protein Binding Cellular Response To Stress Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Folding Chaperone Complex Negative Regulation Of Intracellular Signal Transduction Response To Heat Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Catabolic Process Nucleus Response To Peptide Positive Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process