FBP1 and ASL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FBP1	ASL
Description		fructose-bisphosphatase 1	argininosuccinate lyase
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Protein Binding AMP Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Catalytic Activity Argininosuccinate Lyase Activity Protein Binding Lyase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Response To Nutrient Levels Cellular Response To Insulin Stimulus Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Hyperosmotic Salinity Response Cellular Hypotonic Salinity Response Cellular Response To Raffinose Cellular Response To Phorbol 13-acetate 12-myristate	Urea Cycle Amino Acid Metabolic Process Arginine Metabolic Process L-arginine Biosynthetic Process Locomotory Behavior Amino Acid Biosynthetic Process Post-embryonic Development Ammonia Assimilation Cycle L-arginine Biosynthetic Process Via Ornithine Positive Regulation Of Nitric Oxide Biosynthetic Process L-amino Acid Metabolic Process
Pathways		Gluconeogenesis	Urea cycle
Drugs		Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE	Arginine Argininosuccinate 2-(N-morpholino)ethanesulfonic acid
Diseases		Fructose-1,6-bisphosphatase deficiency	Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)
Interacting Genes		40 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DNMT1 DYNC1I1 ERBB2 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 NOTCH1 PCNX4 PIM2 POT1 PRKN PTK2 PTPRJ RB1 RELA RNF183 STK11 TERF1 TLR2 TRIM28	10 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2 TRIM3
Entrez ID		2203	435
HPRD ID		01973	01948
Ensembl ID		ENSG00000165140	ENSG00000126522
Uniprot IDs		P09467 Q2TU34	A0A024RDL8 A0A0S2Z316 P04424
PDB IDs		1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB 8XBK	1AOS 1K62
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Nervous System Development Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nervous System Development Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Anatomical Structure Morphogenesis Positive Regulation Of Catabolic Process Regulation Of Phosphorylation Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Neurogenesis Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Positive Regulation Of Neurogenesis Programmed Cell Death Regulation Of Growth Cell Death	Protein Serine Kinase Activity Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catabolic Process Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Perivitelline Space Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Protein Kinase CK2 Complex Cellular Hypotonic Salinity Response Cytosol Cellular Response To Cisplatin Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Nuclear Speck Organization
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