FBP1 and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FBP1	FLCN
Description		fructose-bisphosphatase 1	folliculin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP
	Molecular Function	Catalytic Activity Protein Binding AMP Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Response To Nutrient Levels Cellular Response To Insulin Stimulus Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Hyperosmotic Salinity Response Cellular Hypotonic Salinity Response Cellular Response To Raffinose Cellular Response To Phorbol 13-acetate 12-myristate	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Gluconeogenesis	Amino acids regulate mTORC1
Drugs		Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases		Fructose-1,6-bisphosphatase deficiency	Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		40 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DNMT1 DYNC1I1 ERBB2 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 NOTCH1 PCNX4 PIM2 POT1 PRKN PTK2 PTPRJ RB1 RELA RNF183 STK11 TERF1 TLR2 TRIM28	12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2
Entrez ID		2203	201163
HPRD ID		01973	06278
Ensembl ID		ENSG00000165140	ENSG00000154803
Uniprot IDs		P09467 Q2TU34	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB 8XBK	3V42 6NZD 6ULG 8DHB
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Nervous System Development Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nervous System Development Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Anatomical Structure Morphogenesis Positive Regulation Of Catabolic Process Regulation Of Phosphorylation Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Neurogenesis Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Positive Regulation Of Neurogenesis Programmed Cell Death Regulation Of Growth Cell Death	Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity
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