MFAP2 and ELN

Number of citations of the paper that reports this interaction (PMID 11723132)
25

Data Source:
HPRD (in vivo)

		MFAP2	ELN
Gene Name		microfibrillar-associated protein 2	elastin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber
	Molecular Function	Fibronectin Binding Fibrinogen Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Extracellular Matrix Organization Platelet Formation	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs			Rofecoxib
Diseases
GWAS		Height ( 20881960 23563607) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		5 interactors: BGN COL4A3 ELN FBN1 FBN2	21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1
Entrez ID		4237	2006
HPRD ID		01137	00556
Ensembl ID		ENSG00000117122	ENSG00000049540
Uniprot IDs		P55001	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Blood Vessel Remodeling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Tissue Remodeling Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Endothelial Cell Apoptotic Process Sequestering Of BMP In Extracellular Matrix Organ Development Kidney Development Blood Circulation Renal System Development Dermatan Sulfate Biosynthetic Process Bone Trabecula Formation Urogenital System Development Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Stress Fiber Assembly Glomerular Basement Membrane Development Bone Trabecula Morphogenesis System Development Chondroitin Sulfate Biosynthetic Process Skeletal System Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Bone Mineralization Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Peptide Cross-linking Trabecula Morphogenesis Developmental Process Respiratory Gaseous Exchange Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glomerulus Development Collagen Catabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus
Tagcloud ?		capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		capturing clu encompassing etiopathogenesis europeans extraocular fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastin enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?		elastic fbn1