MFAP2 and BGN

Number of citations: 0 (PubMedID 11723132)
Data Source: BioGRID (pull down), HPRD (in vivo)

		MFAP2	BGN
Name		microfibril associated protein 2	biglycan
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Protein Binding Fibrinogen Binding	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Platelet Formation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Positive Regulation Of Cold-induced Thermogenesis	Blood Vessel Remodeling Bone Development Articular Cartilage Development
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 30804561 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Height ( 25429064 25282103 23563607 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for BMI in smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: BGN COL4A3 ELN FBN1 FBN2 HOXA1	21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF
Entrez ID		4237	633
HPRD ID		01137	02359
Ensembl ID		ENSG00000117122	ENSG00000182492
Uniprot IDs		P55001	B4DNL4 P21810
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Microfibril Embryonic Eye Morphogenesis Extracellular Matrix Binding Eye Morphogenesis Maintenance Of Protein Location Sensory Organ Morphogenesis Semicircular Canal Formation Extracellular Region Maintenance Of Location Embryonic Morphogenesis Camera-type Eye Development Basement Membrane Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase A Activity Abducens Nerve Formation Optokinetic Behavior 3 Iron, 4 Sulfur Cluster Binding Animal Organ Morphogenesis Hormone Activity Embryonic Organ Morphogenesis Eye Development Glucose Metabolic Process Succinate Dehydrogenase (quinone) Activity Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Integrin Binding Anatomical Structure Morphogenesis Sequestering Of BMP In Extracellular Matrix Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Response To Food Positive Regulation Of Appetite Respiratory Chain Complex II (succinate Dehydrogenase) Articular Cartilage Development Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Hexose Metabolic Process Negative Regulation Of Osteoclast Development Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Sensory Organ Development Monosaccharide Metabolic Process Collagen Type IV Trimer Carbohydrate Homeostasis Glucose Homeostasis	Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway