MFAP2 and COL4A3

Number of citations: 0 (PubMedID 9278443)
Data Source: HPRD (in vitro)

		MFAP2	COL4A3
Name		microfibril associated protein 2	collagen type IV alpha 3 chain
Structure		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Protein Binding Fibrinogen Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Platelet Formation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Positive Regulation Of Cold-induced Thermogenesis	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Diseases		None	Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 30804561 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Height ( 25429064 25282103 23563607 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for BMI in smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Advanced age-related macular degeneration ( 26691988 ) Central corneal thickness ( 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Diabetic nephropathy in type 1 diabetes ( 31537649 ) Hematuria ( 30476138 ) Hematuria (moderate to severe) ( 30476138 ) Intraocular pressure ( 29235454 ) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649 ) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649 ) Macroalbuminuria in type 1 diabetes ( 31537649 ) Macular thickness ( 30535121 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 )
Interacting Genes		6 interacting genes: BGN COL4A3 ELN FBN1 FBN2 HOXA1	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		4237	1285
HPRD ID		01137	00354
Ensembl ID		ENSG00000117122	ENSG00000169031
Uniprot IDs		P55001	Q01955
PDB IDs		Not available	5NB0 6WKU
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Microfibril Embryonic Eye Morphogenesis Extracellular Matrix Binding Eye Morphogenesis Maintenance Of Protein Location Sensory Organ Morphogenesis Semicircular Canal Formation Extracellular Region Maintenance Of Location Embryonic Morphogenesis Camera-type Eye Development Basement Membrane Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase A Activity Abducens Nerve Formation Optokinetic Behavior 3 Iron, 4 Sulfur Cluster Binding Animal Organ Morphogenesis Hormone Activity Embryonic Organ Morphogenesis Eye Development Glucose Metabolic Process Succinate Dehydrogenase (quinone) Activity Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Integrin Binding Anatomical Structure Morphogenesis Sequestering Of BMP In Extracellular Matrix Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Response To Food Positive Regulation Of Appetite Respiratory Chain Complex II (succinate Dehydrogenase) Articular Cartilage Development Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Hexose Metabolic Process Negative Regulation Of Osteoclast Development Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Sensory Organ Development Monosaccharide Metabolic Process Collagen Type IV Trimer Carbohydrate Homeostasis Glucose Homeostasis	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion