MFAP2

Name	microfibril associated protein 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: SDHB
Interactors	6 interactors: BGN COL4A3 ELN FBN1 FBN2 HOXA1
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Protein Binding Fibrinogen Binding
	Biological Process	Platelet Formation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Positive Regulation Of Cold-induced Thermogenesis
Pathways	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
GWAS	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 30804561 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Height ( 25429064 25282103 23563607 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for BMI in smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	4237
HPRD ID	01137
Ensembl ID	ENSG00000117122
Uniprot IDs	P55001
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Microfibril Embryonic Eye Morphogenesis Extracellular Matrix Binding Eye Morphogenesis Maintenance Of Protein Location Sensory Organ Morphogenesis Semicircular Canal Formation Extracellular Region Maintenance Of Location Embryonic Morphogenesis Camera-type Eye Development Basement Membrane Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase A Activity Abducens Nerve Formation Optokinetic Behavior 3 Iron, 4 Sulfur Cluster Binding Animal Organ Morphogenesis Hormone Activity Embryonic Organ Morphogenesis Eye Development Glucose Metabolic Process Succinate Dehydrogenase (quinone) Activity Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Integrin Binding Anatomical Structure Morphogenesis Sequestering Of BMP In Extracellular Matrix Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Response To Food Positive Regulation Of Appetite Respiratory Chain Complex II (succinate Dehydrogenase) Articular Cartilage Development Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Hexose Metabolic Process Negative Regulation Of Osteoclast Development Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Sensory Organ Development Monosaccharide Metabolic Process Collagen Type IV Trimer Carbohydrate Homeostasis Glucose Homeostasis