MFAP2 and FBN1

Number of citations of the paper that reports this interaction (PMID 11481325)
23

Data Source:
HPRD (in vitro)

		MFAP2	FBN1
Gene Name		microfibrillar-associated protein 2	fibrillin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Fibrinogen Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Extracellular Matrix Organization Platelet Formation	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Height ( 20881960 23563607) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)	Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)
Protein-Protein Interactions		5 interactors: BGN COL4A3 ELN FBN1 FBN2	13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN
Entrez ID		4237	2200
HPRD ID		01137	00618
Ensembl ID		ENSG00000117122	ENSG00000166147
Uniprot IDs		P55001	P35555
PDB IDs			1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Blood Vessel Remodeling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Tissue Remodeling Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Endothelial Cell Apoptotic Process Sequestering Of BMP In Extracellular Matrix Organ Development Kidney Development Blood Circulation Renal System Development Dermatan Sulfate Biosynthetic Process Bone Trabecula Formation Urogenital System Development Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Stress Fiber Assembly Glomerular Basement Membrane Development Bone Trabecula Morphogenesis System Development Chondroitin Sulfate Biosynthetic Process Skeletal System Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Bone Mineralization Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Peptide Cross-linking Trabecula Morphogenesis Developmental Process Respiratory Gaseous Exchange Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glomerulus Development Collagen Catabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway
Tagcloud ?		capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		capturing clu encompassing etiopathogenesis europeans extraocular fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?		elastic fbn1