HAT1 and ACAA1

Number of citations of the paper that reports this interaction (PMID 9427644)
86

Data Source:
BioGRID (enzymatic study)

		HAT1	ACAA1
Gene Name		histone acetyltransferase 1	acetyl-CoA acyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Intracellular Membrane-bounded Organelle Protein Complex	Peroxisome Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity	Acetyl-CoA C-acyltransferase Activity Protein Binding Palmitoyl-CoA Oxidase Activity
	Biological Process	DNA Packaging Chromatin Organization DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Silencing At Telomere Internal Protein Amino Acid Acetylation Response To Nutrient Histone H4 Acetylation	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	alpha-linolenic acid (ALA) metabolism Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Beta-oxidation of very long chain fatty acids Peroxisomal lipid metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACAA1 HIST1H4A HIST2H2AC HIST2H4A HIST3H3 HIST4H4 MEOX2 RBBP4 REL SMAD7 TCF4 TNFAIP1 YWHAQ	2 interactors: HAT1 TXNDC11
Entrez ID		8520	30
HPRD ID		04339	06815
Ensembl ID		ENSG00000128708	ENSG00000060971
Uniprot IDs		O14929	P09110
PDB IDs		2P0W	2IIK
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Histone H4-K20 Demethylation CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Centromere Complex Assembly Protein-DNA Complex Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Methylation On Cytosine ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Negative Regulation Of Gene Expression Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation Nucleosome Assembly DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Nucleosome Organization Chromatin Silencing Histone Lysine Demethylation Histone Demethylation Chromatin Assembly Or Disassembly Protein Demethylation Negative Regulation Of Biosynthetic Process Chromatin Remodeling DNA Packaging Regulation Of Gene Expression, Epigenetic DNA Methylation Demethylation Chromosome Organization Nucleobase-containing Compound Metabolic Process DNA Conformation Change Negative Regulation Of Myeloid Cell Differentiation Cellular Macromolecular Complex Assembly DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Gene Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process	Chromatin Silencing At Telomere DNA Replication-dependent Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly
Tagcloud ?		21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley	100microm 14mm 28mm 50microm acaa2 allocated blastocysts c9t11 cis12 cis9 cla conjugated cpt2 dmso embryos fasn igfbp2 igfbp4 linoleic mentioned periparturitional qpcr scd supplement t10c12 trans10 trans11 unsupplemented zygotes
Tagcloud (Difference) ?		21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley	100microm 14mm 28mm 50microm acaa2 allocated blastocysts c9t11 cis12 cis9 cla conjugated cpt2 dmso embryos fasn igfbp2 igfbp4 linoleic mentioned periparturitional qpcr scd supplement t10c12 trans10 trans11 unsupplemented zygotes
Tagcloud (Intersection) ?