HAT1 and SMAD7

Number of citations of the paper that reports this interaction (PMID 12408818)
58

Data Source:
HPRD (in vitro, in vivo)

		HAT1	SMAD7
Gene Name		histone acetyltransferase 1	SMAD family member 7
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Intracellular Membrane-bounded Organelle Protein Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Catenin Complex Protein Complex
	Molecular Function	Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding
	Biological Process	DNA Packaging Chromatin Organization DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Silencing At Telomere Internal Protein Amino Acid Acetylation Response To Nutrient Histone H4 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein Complex Localization Intracellular Signal Transduction Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Colorectal cancer ( 18372901 18372905 21761138 17934461 23266556) Dental caries ( 23064961) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		13 interactors: ACAA1 HIST1H4A HIST2H2AC HIST2H4A HIST3H3 HIST4H4 MEOX2 RBBP4 REL SMAD7 TCF4 TNFAIP1 YWHAQ	54 interactors: ACVR1B AKT1 ASH1L AXIN1 BMPR1B CTNNB1 CXXC5 DVL1 EP300 ERBB2IP HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MKL2 MYOD1 NEDD4L PARD3 PARD3B PIAS1 PIAS4 RNF111 SASH3 SIRT1 SMAD2 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		8520	4092
HPRD ID		04339	04241
Ensembl ID		ENSG00000128708	ENSG00000101665
Uniprot IDs		O14929	B3KYA8 O15105
PDB IDs		2P0W	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Histone H4-K20 Demethylation CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Centromere Complex Assembly Protein-DNA Complex Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Methylation On Cytosine ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Negative Regulation Of Gene Expression Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation Nucleosome Assembly DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Nucleosome Organization Chromatin Silencing Histone Lysine Demethylation Histone Demethylation Chromatin Assembly Or Disassembly Protein Demethylation Negative Regulation Of Biosynthetic Process Chromatin Remodeling DNA Packaging Regulation Of Gene Expression, Epigenetic DNA Methylation Demethylation Chromosome Organization Nucleobase-containing Compound Metabolic Process DNA Conformation Change Negative Regulation Of Myeloid Cell Differentiation Cellular Macromolecular Complex Assembly DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Gene Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression RNA Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Tissue Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression
Tagcloud ?		21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley	adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate
Tagcloud (Difference) ?		21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley	adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate
Tagcloud (Intersection) ?