EYA3 and DACH1

Number of citations of the paper that reports this interaction (PMID 14628042)
110

Data Source:
HPRD (in vitro)

		EYA3	DACH1
Gene Name		EYA transcriptional coactivator and phosphatase 3	dachshund family transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Involved In Preinitiation Complex Assembly RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Respiratory Gaseous Exchange Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Pathways
Drugs
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Chronic kidney disease ( 20383146) Longevity ( 20834067) Obsessive-compulsive disorder ( 22889921) Urate levels ( 23263486)
Protein-Protein Interactions		6 interactors: DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	18 interactors: AHCYL1 C1orf35 CREBBP EYA1 EYA3 FGF12 JUN NAGK NCOR1 PPIG RNF14 SIN3A SIX1 SMAD3 SMAD4 U2AF2 UBE2I ZCCHC10
Entrez ID		2140	1602
HPRD ID		09042	16031
Ensembl ID		ENSG00000158161	ENSG00000165659
Uniprot IDs		Q99504	Q9UI36
PDB IDs			1L8R
Enriched GO Terms of Interacting Partners?		Regulation Of Branching Involved In Ureteric Bud Morphogenesis Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Olfactory Placode Formation Trigeminal Ganglion Development Regulation Of Satellite Cell Proliferation Metanephros Development Ear Morphogenesis Embryonic Skeletal System Morphogenesis Myoblast Migration Fungiform Papilla Morphogenesis Sensory Organ Development Regulation Of Cell Proliferation Embryonic Skeletal System Development Fungiform Papilla Development Ganglion Development Protein Localization To Nucleus Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Regulation Of Organ Morphogenesis Tongue Morphogenesis Nose Development Pharyngeal System Development Mesenchyme Development Middle Ear Morphogenesis Ear Development Positive Regulation Of Embryonic Development Skeletal System Morphogenesis Positive Regulation Of Kidney Development Tongue Development Kidney Development Muscle Cell Migration Embryonic Organ Morphogenesis Renal System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cranial Nerve Development Urogenital System Development Thymus Development Regulation Of Synapse Assembly Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Organ Development	RNA Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heart Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heart Development Positive Regulation Of Transcription, DNA-templated Ureteric Bud Development Negative Regulation Of Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of Heart Morphogenesis Mesonephros Development Cellular Metabolic Process Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Macromolecule Biosynthetic Process Kidney Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of DNA-templated Transcription In Response To Stress SMAD Protein Signal Transduction Histone Dephosphorylation Response To Transforming Growth Factor Beta Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis
Tagcloud ?			atlas basal bcl2 call chip conclusionthe considerations depend deregulation focused gata3 introductiongata3 luminal mammary methodsgata3 mutated proper regard representing resultswe seq shared shift signatures special subgroup suppressing thsd4 tumorigenesis
Tagcloud (Difference) ?			atlas basal bcl2 call chip conclusionthe considerations depend deregulation focused gata3 introductiongata3 luminal mammary methodsgata3 mutated proper regard representing resultswe seq shared shift signatures special subgroup suppressing thsd4 tumorigenesis
Tagcloud (Intersection) ?