EYA3

Description		EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	DNA Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)
Interacting Genes		9 interacting genes: CRK DACH1 DSCAM DSCR9 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		2140
HPRD ID		09042
Ensembl ID		ENSG00000158161
Uniprot IDs		Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Regulation Of Branching Involved In Ureteric Bud Morphogenesis Fungiform Papilla Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Regulation Of Kidney Development Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cranial Ganglion Development Regulation Of Morphogenesis Of A Branching Structure Tongue Development Regulation Of Morphogenesis Of An Epithelium Metanephric Mesenchyme Development Regulation Of Animal Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Tube Formation Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Population Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Skeletal System Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Ganglion Development Embryonic Organ Morphogenesis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Generation Of Neurons Middle Ear Morphogenesis Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Cell Differentiation Mesenchymal Cell Proliferation Muscle Cell Migration Protein Localization To Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Growth Positive Regulation Of Morphogenesis Of An Epithelium Protein Tyrosine Kinase Binding DNA-binding Transcription Factor Activity Thymus Development Developmental Process Anatomical Structure Morphogenesis Mesenchyme Development Regulation Of Synapse Organization Inner Ear Morphogenesis Regulation Of Transcription By RNA Polymerase II
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