EYA3 and SIX2

Number of citations of the paper that reports this interaction (PMID 12215533)
37

Data Source:
HPRD (in vitro)

		EYA3	SIX2
Gene Name		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Membrane
	Molecular Function	Chromatin Binding Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Sequence-specific DNA Binding
	Biological Process	Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways
Drugs
Diseases
GWAS			Metabolite levels ( 21909109)
Protein-Protein Interactions		6 interactors: DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	5 interactors: AES APP EYA1 EYA3 TLE1
Entrez ID		2140	10736
HPRD ID		09042	05408
Ensembl ID		ENSG00000158161	ENSG00000170577
Uniprot IDs		Q99504	Q8TBA2 Q9NPC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Branching Involved In Ureteric Bud Morphogenesis Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Olfactory Placode Formation Trigeminal Ganglion Development Regulation Of Satellite Cell Proliferation Metanephros Development Ear Morphogenesis Embryonic Skeletal System Morphogenesis Myoblast Migration Fungiform Papilla Morphogenesis Sensory Organ Development Regulation Of Cell Proliferation Embryonic Skeletal System Development Fungiform Papilla Development Ganglion Development Protein Localization To Nucleus Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Regulation Of Organ Morphogenesis Tongue Morphogenesis Nose Development Pharyngeal System Development Mesenchyme Development Middle Ear Morphogenesis Ear Development Positive Regulation Of Embryonic Development Skeletal System Morphogenesis Positive Regulation Of Kidney Development Tongue Development Kidney Development Muscle Cell Migration Embryonic Organ Morphogenesis Renal System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cranial Nerve Development Urogenital System Development Thymus Development Regulation Of Synapse Assembly Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Organ Development	Histone Dephosphorylation Regulation Of Anoikis Anatomical Structure Morphogenesis Positive Regulation Of DNA Repair RNA Metabolic Process Response To Radiation Gene Expression Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Multicellular Organismal Development Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Protein Binding Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of Gene Expression Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Wnt Signaling Pathway Developmental Process Organ Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Anoikis Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Protein Dephosphorylation Neurological System Process Negative Regulation Of Signaling Organ Development Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?			amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?			amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 superficially susceptibile thinning wnt4
Tagcloud (Intersection) ?