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EYA3 and SIX1
Number of citations of the paper that reports this interaction (PMID
12215533
)
37
Data Source:
HPRD
(in vitro)
EYA3
SIX1
Gene Name
EYA transcriptional coactivator and phosphatase 3
SIX homeobox 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Centrosome
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Molecular Function
Chromatin Binding
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Metal Ion Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
Double-strand Break Repair
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Visual Perception
Anatomical Structure Morphogenesis
Response To Ionizing Radiation
Histone Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Positive Regulation Of DNA Repair
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Organ Induction
Kidney Development
Outflow Tract Morphogenesis
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Apoptotic Process
Pattern Specification Process
Skeletal Muscle Tissue Development
Sensory Perception Of Sound
Regulation Of Synaptic Growth At Neuromuscular Junction
Regulation Of Satellite Cell Proliferation
Facial Nerve Morphogenesis
Epithelial Cell Differentiation
Thyroid Gland Development
Olfactory Placode Formation
Regulation Of Protein Localization
Protein Localization To Nucleus
Aorta Morphogenesis
Inner Ear Morphogenesis
Middle Ear Morphogenesis
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Thymus Development
Neuron Fate Specification
Generation Of Neurons
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Inner Ear Development
Regulation Of Epithelial Cell Proliferation
Myoblast Migration
Pharyngeal System Development
Myotome Development
Fungiform Papilla Morphogenesis
Trigeminal Ganglion Development
Otic Vesicle Development
Metanephric Mesenchyme Development
Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Positive Regulation Of Ureteric Bud Formation
Mesonephric Tubule Formation
Ureter Smooth Muscle Cell Differentiation
Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Cochlea Morphogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development
Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Glaucoma (primary open-angle) (
22419738
22570617
)
Optic disc size (rim) (
20395239
)
Vertical cup-disc ratio (
20548946
)
Protein-Protein Interactions
6 interactors:
DACH1
SIX1
SIX2
SIX4
SIX5
ZDHHC17
10 interactors:
AES
CCDC85B
DACH1
EYA1
EYA2
EYA3
EYA4
MDFI
TLE1
VTN
Entrez ID
2140
6495
HPRD ID
09042
03125
Ensembl ID
ENSG00000158161
Uniprot IDs
Q99504
Q15475
PDB IDs
4EGC
Enriched GO Terms of Interacting Partners
?
Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Myotome Development
Positive Regulation Of Ureteric Bud Formation
Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Regulation Of Synaptic Growth At Neuromuscular Junction
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Morphogenesis Of A Branching Structure
Olfactory Placode Formation
Trigeminal Ganglion Development
Regulation Of Satellite Cell Proliferation
Metanephros Development
Ear Morphogenesis
Embryonic Skeletal System Morphogenesis
Myoblast Migration
Fungiform Papilla Morphogenesis
Sensory Organ Development
Regulation Of Cell Proliferation
Embryonic Skeletal System Development
Fungiform Papilla Development
Ganglion Development
Protein Localization To Nucleus
Regulation Of Skeletal Muscle Cell Differentiation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Metanephric Mesenchyme Development
Regulation Of Organ Morphogenesis
Tongue Morphogenesis
Nose Development
Pharyngeal System Development
Mesenchyme Development
Middle Ear Morphogenesis
Ear Development
Positive Regulation Of Embryonic Development
Skeletal System Morphogenesis
Positive Regulation Of Kidney Development
Tongue Development
Kidney Development
Muscle Cell Migration
Embryonic Organ Morphogenesis
Renal System Development
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cranial Nerve Development
Urogenital System Development
Thymus Development
Regulation Of Synapse Assembly
Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Embryonic Organ Development
Histone Dephosphorylation
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
Developmental Process
Peptidyl-tyrosine Dephosphorylation
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein Dephosphorylation
Regulation Of RNA Metabolic Process
Embryonic Morphogenesis
RNA Metabolic Process
Multicellular Organismal Development
Regulation Of Gene Expression
Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Macromolecule Biosynthetic Process
Regulation Of Anoikis
Dephosphorylation
Organ Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryo Development
Middle Ear Morphogenesis
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Cellular Metabolic Process
DNA Repair
Chromatin Modification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Anatomical Structure Development
Positive Regulation Of DNA Repair
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Chromatin Organization
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Stress
Regulation Of Wnt Signaling Pathway
Nitrogen Compound Metabolic Process
Embryonic Organ Morphogenesis
Cellular Response To DNA Damage Stimulus
Regulation Of DNA Repair
Tagcloud
?
as1
atoh7
beadchip
cav1
cav2
cdkn2b
cnvs
cyp1b1
duplications
fndc3b
galc
gas7
glaugen
human660w
interrogated
kilobases
lrp12
merit
myoc
neighbor
optn
penncnv
poag
quad
six6
srbd1
tmco1
wdr36
zfpm2
Tagcloud (Difference)
?
as1
atoh7
beadchip
cav1
cav2
cdkn2b
cnvs
cyp1b1
duplications
fndc3b
galc
gas7
glaugen
human660w
interrogated
kilobases
lrp12
merit
myoc
neighbor
optn
penncnv
poag
quad
six6
srbd1
tmco1
wdr36
zfpm2
Tagcloud (Intersection)
?