EYA3 and SIX4

Number of citations of the paper that reports this interaction (PubMedID 10490620)
42

Data Source:
HPRD (in vitro)

		EYA3	SIX4
Description		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of Synaptic Assembly At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Gene Expression Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CRK DACH1 DSCAM DSCR9 SIX1 SIX2 SIX4 SIX5 ZDHHC17	2 interacting genes: EYA2 EYA3
Entrez ID		2140	51804
HPRD ID		09042	06960
Ensembl ID		ENSG00000158161	ENSG00000100625
Uniprot IDs		Q99504	Q9UIU6
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Regulation Of Branching Involved In Ureteric Bud Morphogenesis Fungiform Papilla Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Regulation Of Kidney Development Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cranial Ganglion Development Regulation Of Morphogenesis Of A Branching Structure Tongue Development Regulation Of Morphogenesis Of An Epithelium Metanephric Mesenchyme Development Regulation Of Animal Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Tube Formation Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Population Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Skeletal System Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Ganglion Development Embryonic Organ Morphogenesis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Generation Of Neurons Middle Ear Morphogenesis Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Cell Differentiation Mesenchymal Cell Proliferation Muscle Cell Migration Protein Localization To Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Growth Positive Regulation Of Morphogenesis Of An Epithelium Protein Tyrosine Kinase Binding DNA-binding Transcription Factor Activity Thymus Development Developmental Process Anatomical Structure Morphogenesis Mesenchyme Development Regulation Of Synapse Organization Inner Ear Morphogenesis Regulation Of Transcription By RNA Polymerase II	Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Repair Phosphoprotein Phosphatase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of DNA Metabolic Process Mesodermal Cell Fate Specification Regulation Of Cellular Response To Stress DNA Repair Mitochondrial Outer Membrane Permeabilization Chromatin Remodeling DNA Metabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death DNA Damage Response Chromatin Organization Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Membrane Permeability Cellular Response To Stress Hydrolase Activity Cell Fate Specification Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitochondrial Membrane Organization Nucleic Acid Metabolic Process Striated Muscle Tissue Development Response To Ionizing Radiation Muscle Tissue Development Cell Differentiation Nucleobase-containing Compound Metabolic Process Visual Perception
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?