EXT1 and FBXW7

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		EXT1	FBXW7
Description		exostosin glycosyltransferase 1	F-box and WD repeat domain containing 7
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Organelle Membrane Synapse Catalytic Complex	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Polysaccharide Biosynthetic Process Cell Morphogenesis Ossification Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Hematopoietic Progenitor Cell Differentiation Hypersensitivity Heart Field Specification Chondrocyte Hypertrophy Endochondral Bone Growth Glycosaminoglycan Biosynthetic Process Protein Glycosylation Vacuole Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Smoothened Signaling Pathway Gastrulation Axon Guidance Brain Development Endoderm Development Mesoderm Development Regulation Of Blood Pressure Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Light Intensity Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neural Crest Cell Differentiation Heparan Sulfate Proteoglycan Biosynthetic Process Stem Cell Division Antigen Processing And Presentation Optic Nerve Development Olfactory Bulb Development Hair Cycle Process Protein Catabolic Process Proteoglycan Biosynthetic Process Collagen Fibril Organization Heparin Proteoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process BMP Signaling Pathway Hair Follicle Morphogenesis Neuron Projection Development Glomerular Basement Membrane Development Cell Adhesion Mediated By Integrin Social Behavior Synaptic Transmission, Glutamatergic Multicellular Organism Growth Chondrocyte Proliferation Limb Joint Morphogenesis Dendritic Cell Migration Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Fluid Transport Wound Healing Vasodilation Fear Response Ossification Involved In Bone Maturation Cellular Response To Fibroblast Growth Factor Stimulus Cell Fate Commitment Bone Resorption Embryonic Morphogenesis Sebaceous Gland Development Chondroitin Sulfate Proteoglycan Metabolic Process Multicellular Organismal-level Water Homeostasis Leukocyte Tethering Or Rolling Sulfation Sodium Ion Homeostasis Heart Contraction Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Morphogenesis Endochondral Bone Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Mesenchyme Development Smoothened Signaling Pathway Involved In Lung Development Developmental Growth Involved In Morphogenesis Sweat Gland Development Hematopoietic Stem Cell Homeostasis Motor Behavior Perichondral Bone Morphogenesis Stomach Development Protein-containing Complex Assembly Dendrite Self-avoidance Response To Growth Factor Response To Heparin Vocalization Behavior Basement Membrane Organization Cellular Response To BMP Stimulus Podocyte Differentiation Embryonic Skeletal Joint Development Lymphocyte Migration Into Lymphoid Organs Hematopoietic Stem Cell Migration To Bone Marrow Cellular Response To Virus Bone Growth Tight Junction Organization Mesenchymal Cell Differentiation Involved In Bone Development Cranial Skeletal System Development Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways		HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Adult body size ( 32376654) Autism spectrum disorder ( 28540026) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Depression in smokers ( 30219690) Endometrial cancer (Non-endometrioid histology) ( 30093612) Facial attractiveness (female raters) ( 30946739) General cognitive ability ( 29844566) Height ( 19893584) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) White blood cell count (basophil) ( 29403010)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: EXT2 FBXW7 GOLPH3 GOLPH3L NOTCH1 TRAP1	84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510
Entrez ID		2131	55294
HPRD ID		00598	05888
Ensembl ID		ENSG00000182197	ENSG00000109670
Uniprot IDs		Q16394	G0Z2K0 Q969H0 S4R3U4
PDB IDs		7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY	2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Golgi Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Gene Expression Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Mitochondrial Intermembrane Space N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Notch Signaling Pathway Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Negative Regulation Of Epithelial Cell Proliferation Auditory Receptor Cell Fate Commitment Notch Signaling Involved In Heart Development Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation Glomerular Mesangial Cell Development Regulation Of Apoptotic Process Cell Migration Involved In Endocardial Cushion Formation Chemical Synaptic Transmission, Postsynaptic Compartment Pattern Specification Mitral Valve Formation	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process
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