EXT1 and EXT2

Number of citations of the paper that reports this interaction (PMID 10639137)
60

Data Source:
HPRD (in vivo, in vitro)

		EXT1	EXT2
Gene Name		exostosin glycosyltransferase 1	exostosin glycosyltransferase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Vesicular Exosome
	Molecular Function	Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Skeletal System Development Ossification Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Gastrulation Axon Guidance Endoderm Development Mesoderm Development Pathogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Olfactory Bulb Development Glycosaminoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Small Molecule Metabolic Process Embryonic Skeletal Joint Development	Ossification Mesoderm Formation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Pathogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Glycosaminoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Height ( 19893584) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: EXT2 TRAP1	10 interactors: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1
Entrez ID		2131	2132
HPRD ID		00598	00599
Ensembl ID			ENSG00000151348
Uniprot IDs		Q16394	Q93063
PDB IDs
Enriched GO Terms of Interacting Partners?		Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Negative Regulation Of Cellular Respiration Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Response To Oxidative Stress Proteoglycan Biosynthetic Process Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Polysaccharide Metabolic Process Mesoderm Formation Mesoderm Morphogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Formation Of Primary Germ Layer Mesoderm Development Carbohydrate Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Pathogenesis	Fetal Process Involved In Parturition Cellular Metabolic Process Glycosaminoglycan Biosynthetic Process Skeletal Muscle Cell Proliferation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Negative Regulation Of Cellular Respiration Digestive Tract Development Digestive System Development Regulation Of Reactive Oxygen Species Metabolic Process Response To Glucocorticoid Response To Corticosteroid Intestinal Epithelial Cell Maturation Glycosaminoglycan Metabolic Process Response To Toxic Substance Response To Cortisol Thymidine Metabolic Process Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Choline Transport Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Anatomical Structure Development Response To Organic Cyclic Compound
Tagcloud ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext2 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies	alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext1 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext1 ext2 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies