MECOM and SUMO1

Number of citations of the paper that reports this interaction (PMID 23770046)
0

Data Source:
BioGRID (enzymatic study)

		MECOM	SUMO1
Gene Name		MDS1 and EVI1 complex locus	small ubiquitin-like modifier 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Aggresome Nuclear Speck Intracellular Membrane-bounded Organelle	Fibrillar Center Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm PML Body Nuclear Speck Dendrite Nuclear Membrane Synapse
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Transcription Factor Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Neutrophil Homeostasis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Inflammatory Response Response To Bacterium Post-embryonic Development Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Pericardium Development Hematopoietic Stem Cell Proliferation Renal System Development	DNA Repair Protein Sumoylation Cytokine-mediated Signaling Pathway PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Palate Development Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Localization To Nuclear Pore
Pathways			Interferon gamma signaling SUMO is proteolytically processed Post-translational protein modification SUMOylation Interferon Signaling Cytokine Signaling in Immune system SUMO is conjugated to E1 (UBA2:SAE1) Regulation of IFNG signaling SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Osteoporosis ( 23349225) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		13 interactors: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 KAT2B MBD3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 SUMO1	194 interactors: ADD3 APP AR ARL13A ATF2 ATF3 ATXN1 ATXN3 ATXN7 AURKA AURKB BCAM BCL11A BIRC3 BLM BRCA1 C11orf65 C18orf25 CAMSAP2 CARD9 CASP2 CASP8 CCDC67 CD40 CDCA8 CHAF1A CHD3 CHD4 COG1 CTNNA1 DAXX DDX24 DNM1 DNMT3A DNMT3B DTX2 EDARADD ESR1 ETV1 ETV4 ETV6 FADD FAM118B FANCM FAS FASLG FBF1 FLI1 FOS FOXL2 FOXM1 GATA1 GLP1R GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HIRA HNF4A HNRNPC HNRNPK HSF1 HSF2 HTT ING2 IRAK1 JUN KAT2A KAT6B KDM1A KRT14 KRT18 KRT5 KRT8 MAP2K1 MAPK1IP1L MDC1 MDM2 MECOM MEF2A MEF2C MITF MKL1 MSX1 MUL1 MX1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NELFE NFE2L2 NFKBIA NIN NOS1 NOX5 NR3C1 NR3C2 PARK7 PARP1 PAX6 PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3C3 PLK3 PML PPARA PPM1J RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBM25 RHOXF2 RNF4 RPS3 SAE1 SALL1 SART1 SATB1 SEMA6A SENP1 SENP2 SENP6 SETX SH3KBP1 SLC2A1 SOX10 SOX2 SOX6 SP1 SP100 SP3 SREBF1 SREBF2 SSRP1 STAB2 STK24 STMN2 SUMO1P1 SUMO2 SUPT7L SYMPK TCERG1 TCF4 TDG TDP2 TFCP2 TGM2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRIM5 TRPS1 TSC22D3 TSHZ2 TSNAX UBA2 UBE2I USP25 USP7 USPL1 WNK1 WRN XRCC1 XRCC5 ZBTB16 ZBTB26 ZBTB6 ZBTB7A ZCCHC12 ZCCHC7 ZMYM2 ZMYM5 ZNF24 ZNF451
Entrez ID		2122	7341
HPRD ID		01310	03554
Ensembl ID		ENSG00000085276	ENSG00000116030
Uniprot IDs		C7FEN9 E7EQ57 Q03112 Q13465	P63165
PDB IDs			1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression SMAD Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Primary MiRNA Processing Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Embryo Development Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Pattern Specification Cellular Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptidyl-lysine Modification	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Apoptotic Process Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Organelle Organization Chromosome Organization Cellular Response To Organic Substance Protein Sumoylation Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Developmental Process Programmed Cell Death Apoptotic Process Peptidyl-lysine Modification
Tagcloud ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation
Tagcloud (Difference) ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation
Tagcloud (Intersection) ?