ESR2 and NCOA6

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ESR2	NCOA6
Gene Name		estrogen receptor 2 (ER beta)	nuclear receptor coactivator 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Neuron Migration Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Brain Development Hormone-mediated Apoptotic Signaling Pathway Gene Expression Negative Regulation Of Cell Growth Intracellular Estrogen Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Negative Regulation Of Androgen Receptor Signaling Pathway Extracellular Negative Regulation Of Signal Transduction	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs		Diethylstilbestrol Raloxifene Tamoxifen Estradiol Trilostane Estramustine Genistein Para-Mercury-Benzenesulfonic Acid N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Estriol Estropipate 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
Diseases
GWAS
Protein-Protein Interactions		88 interactors: AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CCNC CDK8 DAP3 DDX17 DDX5 DDX54 DNTTIP2 EIF3I EP300 ESR1 JMJD1C KAT5 LCK MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NOTCH2NL NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARG PPARGC1A PPP5C PRMT2 PSMC3IP RBFOX2 RBM39 REXO4 RFX6 RXRA SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TRAM1 TRIM24 TRIM59 TRIP4 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		2100	23054
HPRD ID		03390	05599
Ensembl ID		ENSG00000140009	ENSG00000198646
Uniprot IDs		F1D8N3 G3V5M5 Q0PTK2 Q7LCB3 Q92731	F6M2K2 Q14686
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Androgen Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Steroid Hormone Response To Organic Cyclic Compound Metabolic Process Regulation Of Signaling Cellular Response To Hormone Stimulus Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Difference) ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Intersection) ?