Gene Name |
estrogen receptor 2 (ER beta) |
nuclear receptor coactivator 2 |
Image |
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Gene Ontology Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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- PPARA activates gene expression
- Bile acid and bile salt metabolism
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Metabolism of lipids and lipoproteins
- Metabolic disorders of biological oxidation enzymes
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Generic Transcription Pathway
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Cytochrome P450 - arranged by substrate type
- Endogenous sterols
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Activation of gene expression by SREBF (SREBP)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Transcriptional activation of mitochondrial biogenesis
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
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Drugs |
- Diethylstilbestrol
- Raloxifene
- Tamoxifen
- Estradiol
- Trilostane
- Estramustine
- Genistein
- Para-Mercury-Benzenesulfonic Acid
- N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide
- 5-Alpha-Androstane-3-Beta,17beta-Diol
- 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol
- Estriol
- Estropipate
- 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
- 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL
- 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
- 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL
- (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
- 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
- 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
- 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
- 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
- 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL
- (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
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Diseases |
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GWAS |
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- Cardiac Troponin-T levels ( 23247143)
- Metabolite levels (HVA-5-HIAA Factor score) ( 23319000)
- Non-small cell lung cancer ( 23144319)
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Protein-Protein Interactions |
88 interactors:
AKAP13
AKT1
ARID5A
BCAS2
CALM1
CALM2
CALM3
CCNC
CDK8
DAP3
DDX17
DDX5
DDX54
DNTTIP2
EIF3I
EP300
ESR1
JMJD1C
KAT5
LCK
MAD2L1
MAPK1
MAPK11
MED1
MED10
MED12
MED14
MED16
MED17
MED20
MED21
MED23
MED24
MED6
MED7
MEOX2
MKNK2
MMS19
MSH2
NCOA1
NCOA2
NCOA3
NCOA6
NCOA7
NCOR1
NCOR2
NFKBIB
NOTCH2NL
NR0B1
NR0B2
NRIP1
OXT
PELP1
PIAS1
PIAS2
PIAS3
PLSCR1
PNRC1
PNRC2
PPARG
PPARGC1A
PPP5C
PRMT2
PSMC3IP
RBFOX2
RBM39
REXO4
RFX6
RXRA
SERPINH1
SMAD2
SMAD3
SMAD4
SMARCE1
SP1
SRA1
SRC
SREBF1
STAT5A
TRAM1
TRIM24
TRIM59
TRIP4
WIPI1
YWHAH
YWHAQ
ZBTB17
ZNHIT3
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63 interactors:
ACTN2
AHR
ANKRD11
AR
ARNT
BRCA1
CARM1
CCND3
CCNT1
CDK4
CREBBP
CTNNB1
DDX17
DDX5
DLX2
DLX5
EID1
EP300
ESR1
ESR2
ESRRB
ETV1
FOS
GMEB1
HIF1A
HIST3H3
HIST4H4
HNF4A
JUN
KIF5A
KIF5B
KIF5C
MAGEA11
MEF2C
NKX2-1
NR1I2
NR3C1
NR4A1
OPN1LW
PIAS3
PML
PPARA
PPARD
PPARG
PPFIA1
PPFIA4
PRMT1
PSMB9
RARA
RORA
RXRA
SLC30A9
SMARCE1
SRA1
SRCAP
STAT6
SUMO1
TAF9
THRB
TP53
TXNRD2
VDR
YWHAH
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Entrez ID |
2100 |
10499 |
HPRD ID |
03390 |
09066 |
Ensembl ID |
ENSG00000140009
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ENSG00000140396
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Uniprot IDs |
F1D8N3
G3V5M5
Q0PTK2
Q7LCB3
Q92731
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Q15596
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PDB IDs |
1L2J
1NDE
1QKM
1U3Q
1U3R
1U3S
1U9E
1X76
1X78
1X7B
1X7J
1YY4
1YYE
1ZAF
2FSZ
2GIU
2I0G
2JJ3
2NV7
2QTU
2YJD
2YLY
2Z4B
3OLL
3OLS
3OMO
3OMP
3OMQ
4J24
4J26
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1GWQ
1GWR
1M2Z
1MV9
1MVC
1MZN
1P93
1T63
1T65
1UHL
1YOK
1ZDT
1ZDU
1ZKY
2AO6
2B1V
2B1Z
2B23
2FAI
2G44
2G5O
2P15
2P1T
2P1U
2P1V
2Q7J
2Q7L
2ZXZ
2ZY0
3A9E
3CLD
3DZU
3DZY
3E00
3E7C
3E94
3FUG
3GN8
3K22
3K23
3KWY
3KYT
3L0E
3L0J
3L0L
3O1D
3O1E
3OAP
3OZJ
3PCU
3PLZ
3Q95
3Q97
3R5M
3UP0
3UP3
4DOS
4E2J
4FHH
4FHI
4IA1
4IA2
4IA3
4IA7
4IQR
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
25mg
acrosomes
bisphenol
bpa
compromises
disrupts
dosages
epididymis
esr1
fsh
fshb
gnrhr
gonadal
gonadotropin
hypogonadism
hypogonadotropic
hypothalamic
lh
lhb
luteinizing
nontoxic
pituitary
reestablish
reproductive
reserves
sperm
spermatogenesis
spermatozoa
transit
|
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
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Tagcloud (Difference) ? |
25mg
acrosomes
bisphenol
bpa
compromises
disrupts
dosages
epididymis
esr1
fsh
fshb
gnrhr
gonadal
gonadotropin
hypogonadism
hypogonadotropic
hypothalamic
lh
lhb
luteinizing
nontoxic
pituitary
reestablish
reproductive
reserves
sperm
spermatogenesis
spermatozoa
transit
|
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
|
Tagcloud (Intersection) ? |
|