ESR2 and OXT

Number of citations of the paper that reports this interaction (PMID 9501254)
24

Data Source:
HPRD (in vitro)

		ESR2	OXT
Gene Name		estrogen receptor 2 (ER beta)	oxytocin/neurophysin I prepropeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity	Neurohypophyseal Hormone Activity Oxytocin Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Neuron Migration Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Brain Development Hormone-mediated Apoptotic Signaling Pathway Gene Expression Negative Regulation Of Cell Growth Intracellular Estrogen Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Negative Regulation Of Androgen Receptor Signaling Pathway Extracellular Negative Regulation Of Signal Transduction	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Diethylstilbestrol Raloxifene Tamoxifen Estradiol Trilostane Estramustine Genistein Para-Mercury-Benzenesulfonic Acid N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Estriol Estropipate 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Oxytocin
Diseases
GWAS
Protein-Protein Interactions		88 interactors: AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CCNC CDK8 DAP3 DDX17 DDX5 DDX54 DNTTIP2 EIF3I EP300 ESR1 JMJD1C KAT5 LCK MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NOTCH2NL NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARG PPARGC1A PPP5C PRMT2 PSMC3IP RBFOX2 RBM39 REXO4 RFX6 RXRA SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TRAM1 TRIM24 TRIM59 TRIP4 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	5 interactors: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		2100	5020
HPRD ID		03390	08880
Ensembl ID		ENSG00000140009	ENSG00000101405
Uniprot IDs		F1D8N3 G3V5M5 Q0PTK2 Q7LCB3 Q92731	P01178
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Androgen Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Steroid Hormone Response To Organic Cyclic Compound Metabolic Process Regulation Of Signaling Cellular Response To Hormone Stimulus Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Cellular Response To Drug Response To Anoxia Positive Regulation Of Norepinephrine Secretion Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Negative Regulation Of Gastric Acid Secretion Regulation Of Response To Drug Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Gastric Acid Secretion Regulation Of Systemic Arterial Blood Pressure By Vasopressin Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Penile Erection Sperm Ejaculation Maternal Process Involved In Parturition Rhythmic Process Regulation Of Penile Erection Positive Regulation Of Catecholamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Histone H3-K4 Trimethylation Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Synaptic Transmission, GABAergic Sleep Maternal Behavior Histone H4-K16 Acetylation Vagina Development Positive Regulation Of Histone H3-K4 Methylation Insemination Uterus Development ERK1 And ERK2 Cascade Parturition Intracellular Estrogen Receptor Signaling Pathway Epithelial Cell Differentiation Involved In Prostate Gland Development Response To Steroid Hormone Extracellular Negative Regulation Of Signal Transduction Gland Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Organic Substance Copulation Epithelial Cell Maturation Suckling Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Female Genitalia Development Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Negative Regulation Of Receptor Activity Positive Regulation Of Smooth Muscle Contraction Cellular Response To Hormone Stimulus Peptidyl-lysine Trimethylation
Tagcloud ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Difference) ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Intersection) ?