ESR2 and NOTCH2NL

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		ESR2	NOTCH2NL
Gene Name		estrogen receptor 2 (ER beta)	notch 2 N-terminal like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion	Extracellular Region Cytoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity	Calcium Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Neuron Migration Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Brain Development Hormone-mediated Apoptotic Signaling Pathway Gene Expression Negative Regulation Of Cell Growth Intracellular Estrogen Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Negative Regulation Of Androgen Receptor Signaling Pathway Extracellular Negative Regulation Of Signal Transduction	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Diethylstilbestrol Raloxifene Tamoxifen Estradiol Trilostane Estramustine Genistein Para-Mercury-Benzenesulfonic Acid N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Estriol Estropipate 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
Diseases
GWAS
Protein-Protein Interactions		88 interactors: AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CCNC CDK8 DAP3 DDX17 DDX5 DDX54 DNTTIP2 EIF3I EP300 ESR1 JMJD1C KAT5 LCK MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NOTCH2NL NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARG PPARGC1A PPP5C PRMT2 PSMC3IP RBFOX2 RBM39 REXO4 RFX6 RXRA SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TRAM1 TRIM24 TRIM59 TRIP4 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587
Entrez ID		2100	388677
HPRD ID		03390	14833
Ensembl ID		ENSG00000140009	ENSG00000213240
Uniprot IDs		F1D8N3 G3V5M5 Q0PTK2 Q7LCB3 Q92731	Q7Z3S9
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Androgen Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Steroid Hormone Response To Organic Cyclic Compound Metabolic Process Regulation Of Signaling Cellular Response To Hormone Stimulus Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process	Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Tagcloud ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Difference) ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Intersection) ?