KLF6 and KLF4

Number of citations of the paper that reports this interaction (PMID 10802067)
15

Data Source:
HPRD (in vivo)

		KLF6	KLF4
Gene Name		Kruppel-like factor 6	Kruppel-like factor 4 (gut)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromatin Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Metal Ion Binding	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Recruiting Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Phosphatidylinositol 3-kinase Regulator Activity Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Epidermal Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Muscle Hyperplasia Stem Cell Maintenance Post-embryonic Camera-type Eye Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Retinoic Acid Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Maintenance Post-embryonic Hemopoiesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Peptide Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266)	Breast cancer ( 21263130) Prostate cancer ( 23023329)
Protein-Protein Interactions		16 interactors: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53	12 interactors: APP CREBBP ELK1 EP300 HDAC1 HDAC5 KAT5 KLF6 SETD7 SP1 TP53 VHL
Entrez ID		1316	9314
HPRD ID		03632	03769
Ensembl ID		ENSG00000067082	ENSG00000136826
Uniprot IDs		D3GC14 Q99612	O43474
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Fluid Shear Stress Chromatin Organization Gene Expression Regulation Of RNA Metabolic Process Regulation Of DNA Replication Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Component Assembly RRNA Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Notch Signaling Pathway Protein Import Into Nucleus, Translocation Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Histone H3-K9 Modification Transcription, DNA-templated Response To Fluid Shear Stress RNA Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Chromatin Modification Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Neuron Apoptotic Process Negative Regulation Of Signaling Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Response To Hypoxia Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Chromosome Organization Chromatin Modification Response To Stress Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Rhythmic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Interaction With Symbiont Cellular Response To Organic Substance N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		allowed anchorage arrest challenged constitutive conversion decreasing driven ectopic foci g12v highlighting hindering impaired jnk jun knockdown kruppel nih3t3 oncogenic p21 physiology ras relevance spontaneous stably transformed tumorigenesis tumorigenic	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma lna locked maldi multiforme nanog nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		allowed anchorage arrest challenged constitutive conversion decreasing driven ectopic foci g12v highlighting hindering impaired jnk jun knockdown kruppel nih3t3 oncogenic p21 physiology ras relevance spontaneous stably transformed tumorigenesis tumorigenic	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma lna locked maldi multiforme nanog nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?