KLF6 and GTF3C1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KLF6	GTF3C1
Gene Name		Kruppel-like factor 6	general transcription factor IIIC, polypeptide 1, alpha 220kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Nucleolus Membrane Ribonucleoprotein Complex
	Molecular Function	DNA Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Transcription, DNA-templated Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Gene Expression 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266)
Protein-Protein Interactions		16 interactors: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53	21 interactors: AGTRAP AKTIP ASCC2 CHN1 CMTM5 CPE CSNK1E DEDD EZH2 FGFR3 GTF3C4 HGH1 IGFBP3 KLF6 MAGEA4 MAPK10 NHP2L1 PRPF38A RBM23 SUPT5H TBC1D17
Entrez ID		1316	2975
HPRD ID		03632	07540
Ensembl ID		ENSG00000067082	ENSG00000077235
Uniprot IDs		D3GC14 Q99612	Q12789
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Fluid Shear Stress Chromatin Organization Gene Expression Regulation Of RNA Metabolic Process Regulation Of DNA Replication Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Component Assembly RRNA Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Notch Signaling Pathway Protein Import Into Nucleus, Translocation Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Histone H3-K9 Modification Transcription, DNA-templated Response To Fluid Shear Stress RNA Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Chromatin Modification Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Neuron Apoptotic Process Negative Regulation Of Signaling Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process	Positive Regulation Of Metabolic Process Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Catalytic Activity Regulation Of Muscle Cell Differentiation MRNA Processing Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Myoblast Differentiation Positive Regulation Of Phosphorylation Negative Regulation Of Muscle Cell Differentiation RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of DNA-templated Transcription, Elongation MRNA Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Regulation Of MAPK Cascade Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Regulation Of Gliogenesis Heterocycle Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Insulin Processing Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Alveolar Secondary Septum Development 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter JUN Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Axonogenesis Involved In Innervation
Tagcloud ?		allowed anchorage arrest challenged constitutive conversion decreasing driven ectopic foci g12v highlighting hindering impaired jnk jun knockdown kruppel nih3t3 oncogenic p21 physiology ras relevance spontaneous stably transformed tumorigenesis tumorigenic
Tagcloud (Difference) ?		allowed anchorage arrest challenged constitutive conversion decreasing driven ectopic foci g12v highlighting hindering impaired jnk jun knockdown kruppel nih3t3 oncogenic p21 physiology ras relevance spontaneous stably transformed tumorigenesis tumorigenic
Tagcloud (Intersection) ?