NAMPT and GGT1

Number of citations of the paper that reports this interaction (PubMedID 18486613)
34

Data Source:
BioGRID (two hybrid)

		NAMPT	GGT1
Description		nicotinamide phosphoribosyltransferase	gamma-glutamyltransferase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Matrix Cytosol Nuclear Speck Cell Junction Extracellular Exosome	Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	NADP+ Biosynthetic Process Nicotinamide Metabolic Process Inflammatory Response Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD+ Biosynthetic Process Positive Regulation Of Gene Expression Pyridine Nucleotide Biosynthetic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade	Regulation Of Immune System Process Proteolysis Amino Acid Metabolic Process Glutamate Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Nicotinate metabolism NPAS4 regulates expression of target genes	Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes GLUTH Defective GGT1 in aflatoxin detoxification causes GLUTH LTC4-CYSLTR mediated IL4 production Paracetamol ADME
Drugs		GMX1777 Daporinad CHS-828	Glutathione
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Grapefruit juice consumption ( 31046077)	Acne (severe) ( 24927181) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 32084209 33339817) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		7 interacting genes: ADORA2A AKT2 FANCA GGT1 OGT TMEM132D USP49	3 interacting genes: CD53 KCNMA1 NAMPT
Entrez ID		10135	2678
HPRD ID		09938	01980
Ensembl ID		ENSG00000105835	ENSG00000100031
Uniprot IDs		A0A7P0T941 P43490	A0A140VJJ9 P19440
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC 7ENQ 7PPE 7PPF 7PPG 7PPH 7PPI 8DSC 8DSD 8DSE 8DSH 8DSI 8DSM 8DTJ 8F7L 8IVU 8TM7 8Y55	4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?		Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Cell Communication Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Adenosine Receptor Activity Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Translational Initiation Negative Regulation Of Signal Transduction Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Communication Positive Regulation Of Translational Initiation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Response To Insulin Positive Regulation Of Translation Regulation Of Glucose Metabolic Process Response To Hormone Negative Regulation Of Signaling Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Cysteine Biosynthetic Process Leukotriene C4 Gamma-glutamyl Transferase Activity Glutathione Hydrolase Activity Peptide Modification Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Processing Leukotriene D4 Biosynthetic Process Descending Aorta Development Peptidyl-lysine Oxidation Protein-lysine 6-oxidase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ascending Aorta Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex	Blood Vessel Diameter Maintenance Vasodilation Regulation Of Tube Size Identical Protein Binding Renal System Process Large Conductance Calcium-activated Potassium Channel Activity Micturition Nicotinamide Phosphoribosyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Nicotinamide Metabolic Process G Protein-coupled Adenosine Receptor Activity Postsynaptic Membrane Negative Regulation Of Cell Volume Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Vascular Process In Circulatory System NADP+ Biosynthetic Process Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of ERK1 And ERK2 Cascade Circulatory System Process G Protein-coupled Adenosine Receptor Signaling Pathway Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Positive Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Calcium-activated Potassium Channel Activity Synaptic Transmission, Dopaminergic Prepulse Inhibition Asymmetric Synapse Axolemma Alpha-actinin Binding Response To Caffeine NAD+ Biosynthetic Process Via The Salvage Pathway Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Myoblast Fusion Positive Regulation Of MAPK Cascade Astrocyte Activation Negative Regulation Of Vascular Permeability Intracellular Potassium Ion Homeostasis Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Regulation Of Glutamate Secretion
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