NAMPT and USP49

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAMPT	USP49
Description		nicotinamide phosphoribosyltransferase	ubiquitin specific peptidase 49
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Matrix Cytosol Nuclear Speck Cell Junction Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity
	Biological Process	NADP+ Biosynthetic Process Nicotinamide Metabolic Process Inflammatory Response Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD+ Biosynthetic Process Positive Regulation Of Gene Expression Pyridine Nucleotide Biosynthetic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Nicotinate metabolism NPAS4 regulates expression of target genes	Ub-specific processing proteases
Drugs		GMX1777 Daporinad CHS-828
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Grapefruit juice consumption ( 31046077)	Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 20139978 32888494) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		7 interacting genes: ADORA2A AKT2 FANCA GGT1 OGT TMEM132D USP49	11 interacting genes: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
Entrez ID		10135	25862
HPRD ID		09938	10075
Ensembl ID		ENSG00000105835	ENSG00000164663
Uniprot IDs		A0A7P0T941 P43490	Q70CQ1
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC 7ENQ 7PPE 7PPF 7PPG 7PPH 7PPI 8DSC 8DSD 8DSE 8DSH 8DSI 8DSM 8DTJ 8F7L 8IVU 8TM7 8Y55
Enriched GO Terms of Interacting Partners?		Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Cell Communication Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Adenosine Receptor Activity Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Translational Initiation Negative Regulation Of Signal Transduction Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Communication Positive Regulation Of Translational Initiation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Response To Insulin Positive Regulation Of Translation Regulation Of Glucose Metabolic Process Response To Hormone Negative Regulation Of Signaling Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Cysteine Biosynthetic Process Leukotriene C4 Gamma-glutamyl Transferase Activity Glutathione Hydrolase Activity Peptide Modification Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Processing Leukotriene D4 Biosynthetic Process Descending Aorta Development Peptidyl-lysine Oxidation Protein-lysine 6-oxidase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ascending Aorta Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex	Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation
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