NAMPT

Gene Name		nicotinamide phosphoribosyltransferase
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Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Protein Homodimerization Activity Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Signal Transduction Cell-cell Signaling Female Pregnancy Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Response To Organic Cyclic Compound NAD Metabolic Process Circadian Regulation Of Gene Expression Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: ADORA2A AKT2 FANCA GGT1
Entrez ID		10135
HPRD ID		09938
Ensembl ID		ENSG00000105835
Uniprot IDs		P43490
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
Enriched GO Terms of Interacting Partners?		Glutathione Catabolic Process Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cysteine Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cysteine Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Adenosine Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Peptide Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process CAMP Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Lipid Transport Myelin Maintenance Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Positive Regulation Of Lipid Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Activation Of Adenylate Cyclase Activity Peptide Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glucose Import Cellular Response To Stimulus Myelination In Peripheral Nervous System CAMP Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Glucose Transport
Tagcloud ?		atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize