NAMPT and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		NAMPT	TMEM132D
Description		nicotinamide phosphoribosyltransferase	transmembrane protein 132D
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Matrix Cytosol Nuclear Speck Cell Junction Extracellular Exosome	Membrane
	Molecular Function	Cytokine Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity	Protein Binding
	Biological Process	NADP+ Biosynthetic Process Nicotinamide Metabolic Process Inflammatory Response Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD+ Biosynthetic Process Positive Regulation Of Gene Expression Pyridine Nucleotide Biosynthetic Process Circadian Regulation Of Gene Expression NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Nicotinate metabolism NPAS4 regulates expression of target genes
Drugs		GMX1777 Daporinad CHS-828
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Grapefruit juice consumption ( 31046077)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		7 interacting genes: ADORA2A AKT2 FANCA GGT1 OGT TMEM132D USP49	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		10135	121256
HPRD ID		09938	13906
Ensembl ID		ENSG00000105835	ENSG00000151952
Uniprot IDs		A0A7P0T941 P43490	Q14C87
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC 7ENQ 7PPE 7PPF 7PPG 7PPH 7PPI 8DSC 8DSD 8DSE 8DSH 8DSI 8DSM 8DTJ 8F7L 8IVU 8TM7 8Y55
Enriched GO Terms of Interacting Partners?		Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Cell Communication Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Adenosine Receptor Activity Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Translational Initiation Negative Regulation Of Signal Transduction Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Communication Positive Regulation Of Translational Initiation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Response To Insulin Positive Regulation Of Translation Regulation Of Glucose Metabolic Process Response To Hormone Negative Regulation Of Signaling Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Cysteine Biosynthetic Process Leukotriene C4 Gamma-glutamyl Transferase Activity Glutathione Hydrolase Activity Peptide Modification Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Processing Leukotriene D4 Biosynthetic Process Descending Aorta Development Peptidyl-lysine Oxidation Protein-lysine 6-oxidase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ascending Aorta Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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