ERCC4 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 11401546)
0

Data Source:
HPRD (in vitro)

		ERCC4	SPTAN1
Description		ERCC excision repair 4, endonuclease catalytic subunit	spectrin alpha, non-erythrocytic 1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome ERCC4-ERCC1 Complex	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Telomerase Inhibitor Activity Hydrolase Activity Identical Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Cellular Response To UV Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 28991256 30285260 25056061) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		12 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333
Entrez ID		2072	6709
HPRD ID		00594	01684
Ensembl ID		ENSG00000175595	ENSG00000197694
Uniprot IDs		A0A1W1GSK9 A0A804HKF9 B4DXD8 Q92889	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs		1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB	2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair DNA Repair Positive Regulation Of T-circle Formation DNA Metabolic Process Double-strand Break Repair Telomere Maintenance DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair T-circle Formation Damaged DNA Binding DNA Double-strand Break Processing Single-stranded DNA Binding Slx1-Slx4 Complex Cellular Response To Stress Negative Regulation Of Telomere Maintenance Chromosome Organization ERCC4-ERCC1 Complex Organelle Organization Chromosome, Telomeric Region Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly DNA Replication Factor A Complex Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Nucleobase-containing Compound Metabolic Process Mitotic Recombination Negative Regulation Of DNA Metabolic Process DNA Replication Nucleus Nuclear Thyroid Hormone Receptor Binding Mismatch Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleoplasm Telomere Maintenance Via Telomere Lengthening Base-excision Repair Response To Stress Interstrand Cross-link Repair Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Via Single-strand Annealing	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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