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ERCC4
Gene Name
excision repair cross-complementation group 4
Image
Gene Ontology Annotations
Cellular Component
Nucleotide-excision Repair Complex
Nucleotide-excision Repair Factor 1 Complex
Chromosome, Telomeric Region
Nuclear Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
TFIID-class Transcription Factor Binding
Damaged DNA Binding
Single-stranded DNA Binding
Endodeoxyribonuclease Activity
Protein Binding
Protein C-terminus Binding
Structure-specific DNA Binding
Protein N-terminus Binding
Biological Process
Resolution Of Meiotic Recombination Intermediates
Nucleotide-excision Repair, DNA Damage Removal
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Catabolic Process, Endonucleolytic
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Response To UV
UV Protection
Telomere Maintenance Via Telomere Shortening
Negative Regulation Of Telomere Maintenance
Nucleotide-excision Repair, DNA Incision
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Nucleotide Excision Repair
Global Genomic NER (GG-NER)
Transcription-coupled NER (TC-NER)
Formation of incision complex in GG-NER
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in GG-NER
Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Bilirubin levels (
22085899
)
Conduct disorder (symptom count) (
20585324
)
Metabolic syndrome (
20694148
)
Protein-protein Interactions
7 interactors:
ERCC1
FANCG
GTF2H1
RAD52
SLX1A
SLX4
SPTAN1
Entrez ID
2072
HPRD ID
00594
Ensembl ID
ENSG00000175595
Uniprot IDs
Q92889
PDB IDs
1Z00
2A1J
2AQ0
2KN7
Enriched GO Terms of Interacting Partners
?
DNA Repair
Cellular Response To DNA Damage Stimulus
DNA Catabolic Process
Double-strand Break Repair
DNA Metabolic Process
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
DNA Recombination
Cellular Response To Stress
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Nucleotide-excision Repair
DNA Catabolic Process, Endonucleolytic
DNA Double-strand Break Processing
Aromatic Compound Catabolic Process
Nucleotide-excision Repair, DNA Damage Removal
DNA Catabolic Process, Exonucleolytic
Cellular Macromolecule Catabolic Process
Response To Stress
Transcription-coupled Nucleotide-excision Repair
Nucleic Acid Phosphodiester Bond Hydrolysis
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Stimulus
Post-embryonic Hemopoiesis
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nitrogen Compound Metabolic Process
Catabolic Process
Pyrimidine Dimer Repair By Nucleotide-excision Repair
Response To Intra-S DNA Damage Checkpoint Signaling
DNA Recombinase Assembly
Gonad Development
Nucleotide-excision Repair, DNA Incision
Replicative Cell Aging
Development Of Primary Sexual Characteristics
Interstrand Cross-link Repair
Germ Cell Development
Cellular Response To Stimulus
Negative Regulation Of Telomere Maintenance
Sex Differentiation
Pyrimidine Dimer Repair
UV Protection
Response To Sucrose
Regulation Of Telomere Maintenance
Response To Radiation
Isotype Switching
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Tagcloud
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additively
additivity
adducts
african
americans
bonferroni
bulky
cancerous
carolina
corrected
departures
ds
eradicate
ercc2
hnc
interacted
jointly
ner
os
platinum
remove
rs2607755
rs3136038
rs3136130
rs50871
suggestively
uncorrected
whites
xpc