ERCC4 and RAD52

Number of citations of the paper that reports this interaction (PubMedID 14734547)
0

Data Source:
HPRD (in vitro, in vivo)

		ERCC4	RAD52
Description		ERCC excision repair 4, endonuclease catalytic subunit	RAD52 DNA repair protein
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Telomerase Inhibitor Activity Hydrolase Activity Identical Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Cellular Response To UV Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 28991256 30285260 25056061) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)	Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		12 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		2072	5893
HPRD ID		00594	11855
Ensembl ID		ENSG00000175595	ENSG00000002016
Uniprot IDs		A0A1W1GSK9 A0A804HKF9 B4DXD8 Q92889	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair DNA Repair Positive Regulation Of T-circle Formation DNA Metabolic Process Double-strand Break Repair Telomere Maintenance DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair T-circle Formation Damaged DNA Binding DNA Double-strand Break Processing Single-stranded DNA Binding Slx1-Slx4 Complex Cellular Response To Stress Negative Regulation Of Telomere Maintenance Chromosome Organization ERCC4-ERCC1 Complex Organelle Organization Chromosome, Telomeric Region Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly DNA Replication Factor A Complex Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Nucleobase-containing Compound Metabolic Process Mitotic Recombination Negative Regulation Of DNA Metabolic Process DNA Replication Nucleus Nuclear Thyroid Hormone Receptor Binding Mismatch Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleoplasm Telomere Maintenance Via Telomere Lengthening Base-excision Repair Response To Stress Interstrand Cross-link Repair Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Via Single-strand Annealing	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress
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