ERCC4 and SLX4

Number of citations of the paper that reports this interaction (PMID 19596236)
118

Data Source:
HPRD (two hybrid, in vivo)

		ERCC4	SLX4
Gene Name		excision repair cross-complementation group 4	SLX4 structure-specific endonuclease subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor TFIID Complex	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleoplasm Cytoplasm Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Structure-specific DNA Binding Protein N-terminus Binding	Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Catalytic Activity Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS		Bilirubin levels ( 22085899) Conduct disorder (symptom count) ( 20585324) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		7 interactors: ERCC1 FANCG GTF2H1 RAD52 SLX1A SLX4 SPTAN1	7 interactors: APP EME1 ERCC4 MUS81 SLX1A SLX4IP UBC
Entrez ID		2072	84464
HPRD ID		00594	12537
Ensembl ID		ENSG00000175595	ENSG00000188827
Uniprot IDs		Q92889	Q8IY92
PDB IDs		1Z00 2A1J 2AQ0 2KN7	4M7C
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair DNA Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing DNA Recombination Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Exonucleolytic Cellular Macromolecule Catabolic Process Response To Stress Transcription-coupled Nucleotide-excision Repair Nucleic Acid Phosphodiester Bond Hydrolysis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Post-embryonic Hemopoiesis Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nitrogen Compound Metabolic Process Catabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombinase Assembly Gonad Development Nucleotide-excision Repair, DNA Incision Replicative Cell Aging Development Of Primary Sexual Characteristics Interstrand Cross-link Repair Germ Cell Development Cellular Response To Stimulus Negative Regulation Of Telomere Maintenance Sex Differentiation Pyrimidine Dimer Repair UV Protection Response To Sucrose Regulation Of Telomere Maintenance Response To Radiation Isotype Switching Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter	DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Metabolic Process DNA Catabolic Process, Endonucleolytic DNA Catabolic Process Cellular Response To Stress Response To Stress Cellular Macromolecule Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Regulation Of ERBB Signaling Pathway Recombinational Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Double-strand Break Repair Collateral Sprouting In Absence Of Injury DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Telomere Maintenance Via Telomere Shortening Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nucleotide-excision Repair, DNA Incision Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Neuron Remodeling Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance
Tagcloud ?		additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc	btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf
Tagcloud (Difference) ?		additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc	btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf
Tagcloud (Intersection) ?